Correlation between plasma TMAO level and DR in patients with T2DM

WANG Hong; LI Xiaojing; LIU Jia; WANG Linin; CUI Liqin; DONG Song

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Medical Journal of the Chinese People Armed Police Forces ›› 2022, Vol. 33 ›› Issue (8) : 654-658.

Correlation between plasma TMAO level and DR in patients with T2DM

WANG Hong, LI Xiaojing, LIU Jia, WANG Linin, CUI Liqin, DONG Song

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Abstract

Objective To investigate the correlation of plasma trimethylamine-N-oxide (TMAO) level with diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).Methods One hundred and one patients with T2DM admitted into the endocrinology department of Aerospace Center Hospital were enrolled in this study and divided into DR group (n=32) and without-DR group (n=69). Plasma TMAO level was measured by the ELISA method, and the Logistic regression and receiver operating characteristic (ROC) curve were used to analyze the relationship between plasma TMAO level and DR.Results The DR patients were older and showed higher duration of diabetes, systolic blood pressure and plasma TMAO level than without-DR group (P＜0.05), while serum albumin and triglycerides in DR group were lower (P＜0.05). Logistic regression analysis found that, after adjustment for confounding factor, the age (OR=1.070, 95%CI:1.011-1.133, P=0.019), serum albumin (OR=0.807, 95%CI:0.701-0.929, P=0.003), and plasma TMAO (OR=1.062, 95%CI:1.006-1.121,P=0.029) were independently associated with DR. Based on ROC analysis, the area under curve (AUC) of plasma TMAO alone was 0.650(P=0.024), and the AUC of age, serum albumin and plasma TMAO in combination was 0.789(P＜0.001).Conclusion DR patients show a higher plasma TMAO level. The combination of plasma TMAO, age and serum albumin is characterized by a higher predicting ability for DR.

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trimethylamine-N-oxide / type 2 diabetes mellitus / diabetic retinopathy

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WANG Hong, LI Xiaojing, LIU Jia, WANG Linin, CUI Liqin, DONG Song. Correlation between plasma TMAO level and DR in patients with T2DM[J]. Medical Journal of the Chinese People Armed Police Forces. 2022, 33(8): 654-658

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