Application of closed negative pressure drainage combined with Beifuxin in treatment of pressure injury

LI Yan; SHI Changqian; JI Shengbo; TONG Yan; ZHANG Guiquan; LIN Lin; XU Xuebing

PDF(997 KB)

Medical Journal of the Chinese People Armed Police Forces ›› 2023, Vol. 34 ›› Issue (12) : 1034-1037.

Application of closed negative pressure drainage combined with Beifuxin in treatment of pressure injury

LI Yan¹, SHI Changqian², JI Shengbo¹, TONG Yan¹, ZHANG Guiquan¹, LIN Lin¹, XU Xuebing¹

Author information +

History +

Abstract

Objective To explore the application effect of closed negative pressure drainage combined with Beifuxin in the treatment of pressure injury. Methods Fifty-two patients with stress injury who were hospitalized in Liaoning Provincial Corps Hospital of Chinese People’s Armed Police Force from January 2014 to October 2022 were selected as the research subjects, and randomly divided into observation group (n=26) and control group (n=26) according to the admission sequence number. After the installation of closed negative pressure drainage device in debridement for both groups, the control group was treated with conventional closed negative pressure drainage, and the observation group was treated with closed negative pressure drainage combined with Beifuxin. The levels of pain score (VAS), pressure sore score (Braden), expression of chemokines SDF-1α and CXCR4, and wound healing rate at 7 d, 14 d and 21d after surgery were observed and compared between the two groups before and after the treatment. Results VAS score and Braden score in the two groups were significantly improved after treatment, and the observation group was significantly better than the control group (P<0.05).The protein expression levels of SDF-1α and CXCR4 in the observation group were significantly higher than those in the control group after treatment (P<0.05).The wound healing rate of the two groups gradually increased with the prolongation of treatment time, and the wound healing rate of the observation group was consistently higher than that of the control group (P<0.05). The total effective rate of the observation group and the control group was 92.31% and 84.61% respectively, and the therapeutic effect of the observation group was significantly better than that of the control group (P<0.05). Conclusions The technique of closed negative pressure drainage combined with Beifuxin is effective in the treatment of pressure injury, which can better promote wound healing.

Key words

stress injury / closed negative pressure drainage / Beifuxin / clinical curative effect

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

LI Yan, SHI Changqian, JI Shengbo, TONG Yan, ZHANG Guiquan, LIN Lin, XU Xuebing. Application of closed negative pressure drainage combined with Beifuxin in treatment of pressure injury[J]. Medical Journal of the Chinese People Armed Police Forces. 2023, 34(12): 1034-1037

References

[1] Headlam J,Illsley A.Pressure ulcers: an overview[J]. Brit J Hosp Med,2020,81(12):1-9.
[2] Defa A,Kazuhiro O,Tamae U,et al.Development of recurrent pressure ulcers, risk factors in older patients:a prospective observational study[J]. J Wound Care,2020,29(Sup4):14-24.
[3] 张锦锦,田丽,王晓萍,等.压疮处理效果评价指标的循证分析[J].护理研究,2017,31(15):1828-1831.
[4] Borys S,Hohendorff J,Koblik T,et al.Negative-pressure wound therapy for management of chronic neuropathic noninfected diabetic foot ulcerations-short-term efficacy and long-term outcomes[J].Endocrine, 2018,62(3):611-616.
[5] 朱思文,张莉,蒋邦红,等.富血小板血浆联合负压封闭引流技术治疗慢性难愈性创面的研究[J].中华全科医学,2021,19(2):205-208.
[6] 孟素玉,赵鹏,马雅宁,等.重组牛碱性成纤维细胞生长因子治疗烧伤创面的效果观察[J].临床合理用药杂志,2020,13(26):90-92.
[7] National pressure ulcer advisory panel,European pressure ulcer advisory panel and pan pacific pressure injury alliance. Prevention and treatment of pressure ulcers:quick reference guide[R].Cambridge Media:OsbornePark,Western Australia,2014.
[8] 肖慧,白雪,余亦程,等.黄芪甲苷对高糖受损人内皮祖细胞分泌SDF-1α和CXCR4的影响[J].中医药导报,2020,26(12):1-4.
[9] 李妍.封闭负压引流技术联合贝复新在压力性损伤治疗中的应用研究[D].沈阳:中国医科大学,2020.
[10] 刘凤,赵国平,秦汉兴,等.负压封闭引流3种不同负压值对Ⅲ期、Ⅳ期压力性溃疡治疗效果的影响[J].护理研究,2018,32(1):123-124.
[11] 许斌,贺彦,丁涛.不同压力值对负压封闭引流技术治疗的影响研究[J].医疗装备,2018,31(14):95-96.
[12] 刘浩,孙磊,齐岩,等.封闭负压引流修复严重软组织损伤:多种因素联合应用的评价[J].中国组织工程研究,2014,18(47):7666-7671.
[13] 邱学文,龚震宇.封闭负压引流对兔压力性溃疡创面组织水肿及血流量的影响[J].广西医学,2014,36(5):599-601.
[14] 冯光,郝岱峰,张新健,等.坐骨结节压力性损伤的分型及修复策略[J].中华损伤与修复杂志(电子版),2019,14(5):339-343.
[15] 王思佳,刘进辉,刘冬梅,等.Ⅲ级～Ⅳ级骶尾部压疮不同治疗方法效果评价对比研究[J].吉林医学,2021,42(4):835-838.
[16] Jing Z,Zhiguo L.Successful management of wound dehiscence after total knee arthroplasty by topically using recombinant basic fibroblast growth factor[J].Case Rep Clin Med,2020,09(6):154-157.
[17] Piao W,Hao Z,Yao Y,et al.Repair of facial nerve crush injury in rabbits using collagen plus basic fibroblast growth factor[J]. J Biomed Mater Res A,2020,108(6):1329-1337.
[18] 张留馨,张茹,钟玉玲,等.压力性损伤相关性疼痛概念分析[J].中华现代护理杂志,2020,26(31):4428-4431.
[19] 蔡浩,李文婷,练祝平,等.贝复新联合封闭式负压引流治疗外科难愈性伤口的疗效研究[J].中国医药科学,2018,8(2):202-204.
[20] 何灿粲,计晓娟,余更生,等.过表达趋化因子受体4的内皮祖细胞影响血管平滑肌细胞迁移、增殖[J].第三军医大学学报,2017,39(15):1562-1568.
[21] 陈滔,郑鑫,黄杨,等.富血小板血浆通过调节SDF-1/CXCR4信号通路影响糖尿病皮瓣新生血管化机制的研究[J].中华全科医学,2016,14(6):953-956.