Efficacy of sintilimab combined with chemotherapy in the first-line treatment of advanced gastric cancer or gastroesophageal junction adenocarcinoma

LI Juan; YE Sisi; ZHANG Pengfei; BAI Li

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Medical Journal of the Chinese People Armed Police Forces ›› 2023, Vol. 34 ›› Issue (6) : 476-480.

Efficacy of sintilimab combined with chemotherapy in the first-line treatment of advanced gastric cancer or gastroesophageal junction adenocarcinoma

LI Juan, YE Sisi, ZHANG Pengfei, BAI Li

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Abstract

Objective To retrospectively analyze the efficacy of sintilimab combined with chemotherapy in the first-line treatment of advanced gastric or gastroesophageal junction adenocarcinoma(GC or GEJC). Methods Clinical data of patients with advanced GC or GEJC who received first-line sintilimab combined with chemotherapy at the First Medical Center of the Chinese PLA General Hospital from January 2019 to October 2022 were collected. Median progression-free survival (mPFS), objective response rate (ORR), and disease control rate (DCR) of enrolled patients were retrospectively analyzed. Results A total of 71 patients were included, with a median age of 60, including 53 males and 18 females. Forty-five patients were treated with sintilimab combined with oxaliplatin based regimen, while 26 patients were treated with sintilimab combined with albumin-bound paclitaxel (nab-paclitaxel) based regimen. The ORR, DCR and mPFS of all patients were 67.6%, 97.2% and 11.2 months (95% CI 9.7-12.8), respectively. The ORR, DCR and mPFS of oxaliplatin-based combination group were 73.3%, 97.8% and 11.3 months (95%CI 5.5-17.2), while the ORR, DCR and mPFS of nab-paclitaxel-based combination group were 57.7%, 96.2% and 10.9 months (95%CI 9.0-12.9). There was no significant difference in ORR and PFS between the two groups. Conclusions The first-line application of sintilimab combined with chemotherapy in advanced GC or GEJC can significantly benefit the mPFS of patients. In addition, the efficacy of sintilimab combined with nab-paclitaxel-based treatment is comparable with that with oxaliplatin-based treatment.

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gastric cancer / sintilimab / first-line treatment / Oxaliplatin / nab-paclitaxel

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LI Juan, YE Sisi, ZHANG Pengfei, BAI Li. Efficacy of sintilimab combined with chemotherapy in the first-line treatment of advanced gastric cancer or gastroesophageal junction adenocarcinoma[J]. Medical Journal of the Chinese People Armed Police Forces. 2023, 34(6): 476-480

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