Objective To investigate the effect of genetic polymorphism of EDN1 gene on the incidence of type 2 diabetic nephropathy among the Han nationality in northern China. Methods This study involved 120 Han population, including 60 patients with type 2 diabetic nephropathy and 60 patients with type 2 diabetes but without nephropathy matched by sex and age. Polymorphisms of EDN1 rs5370 locus were detected using polymerase chain reaction (PCR) techniques. Results Serum levels of total cholesterol, triglycerides, low-density lipoprotein, creatinine and uric acid were notably elevated in the diabetic nephropathy group compared with the non-nephropathy diabetes group. There was a significant difference in the distribution of the EDN1 rs5370 alleles between the groups. Individuals with T/T genotype had a significantly lower risk of diabetic nephropathy compared to those with G/G genotype [OR=0.357, 95%CI(0.132-0.963), P=0.042]. Additionally, individuals with T allele had a significantly lower risk of diabetic nephropathy compared to those with G allele [OR=0.565, 95%CI(0.339-0.942), P=0.029]. Conclusions The rs5370 polymorphism of EDN1 gene may be associated with the risk of type 2 diabetic nephropathy, especially the T allele may offer a protective effect. These findings provide important insights into the genetic mechanisms of diabetic nephropathy and may influence future strategies for prevention and treatment.
Key words
diabetic nephropathy /
EDN1 /
gene polymorphism
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