Clinicopathological features of sclerosing angiomatoid nodular transformation

YU Lan; DING Huizhen; GAO Yiqun; LU Ping; ZHANG Jing

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Medical Journal of the Chinese People Armed Police Forces ›› 2024, Vol. 35 ›› Issue (7) : 567-571.

ORIGINAL ARTICLES

Clinicopathological features of sclerosing angiomatoid nodular transformation

YU Lan¹, DING Huizhen², GAO Yiqun³, LU Ping³, ZHANG Jing⁴

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Abstract

Objective To investigate the clinicopathological features of sclerosing angiomatoid nodular transformation(SANT). Methods Clinical data of SANT patients in the Fourth and Sixth Medical Center of PLA General Hospital from 2016 to 2022 were collected, and the clinicopathological features, imaging features and immunohistochemical data were analyzed. Results A total of 7 cases were found, including 5 males and 2 females, aged 32-49 years with an average age of 42.3 years. Six cases were single, with a maximum diameter of 3.0-14.5 cm (average 7.4 cm), and 1 case was multiple, with a maximum diameter of 5.7 cm×5 cm×3.5 cm, with a minimum diameter of 0.7 cm×0.6 cm×0.6 cm. Microscopically, there were multiple hemangiomatous nodules surrounded by fibers. The vascular components in the nodules were complex, which were like splenic sinus, capillary or venous. The expressions of CD34, CD31, and CD8 in vascular endothelial cells were different. The SMA expression in peripheral spindle cells was focally positive. EBER detection results of in situ hybridization were negative. Conclusions SANT is a rare benign vascular lesion with unique pathological features, which has no clinical symptoms and is easy to be misdiagnosed. It can be cured by surgical resection. Postoperative pathological morphology and immunohistochemical staining are important methods for definite diagnosis.

Key words

spleen / sclerosing angiomatoid nodular transformation / clinical pathology / differential diagnosis

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YU Lan, DING Huizhen, GAO Yiqun, LU Ping, ZHANG Jing. Clinicopathological features of sclerosing angiomatoid nodular transformation[J]. Medical Journal of the Chinese People Armed Police Forces. 2024, 35(7): 567-571

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