Predictive value of bone age, luteinizing hormone/follicle-stimulating hormone ratio combined with serum 25-hydroxyvitamin D level for rapidly progressive central precocious puberty

LUO Yun; TAN Lilan; ZHANG Meng

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Medical Journal of the Chinese People Armed Police Forces ›› 2025, Vol. 36 ›› Issue (10) : 829-834.

Predictive value of bone age, luteinizing hormone/follicle-stimulating hormone ratio combined with serum 25-hydroxyvitamin D level for rapidly progressive central precocious puberty

LUO Yun¹, TAN Lilan², ZHANG Meng¹

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Abstract

Objective To explore the predictive value of bone age, luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratio combined with serum 25-hydroxyvitamin D[25-(OH)D] level for rapidly progressive central precocious puberty (RP-CPP). Methods A retrospective study was conducted on 116 girls with central precocious puberty (CPP) admitted to Jiangxi Provincial Corps Hospital of Chinese People’s Armed Police Force and Nanchang People’s Hospital from January 2021 to July 2023. These girls were divided into RP-CPP group (n=42) and the slowly progressive central precocious puberty (SP-CPP) group (n=74) based on their pubertal development process and other indicators. Another 50 girls with CPP were selected from the same hospitals from August 2023 to June 2024 at a ratio of 7∶3 as the validation group, which was further divided into the RP-CPP group (n=16) and the SP-CPP group (n=34). The constructed prediction model was externally validated. The data of the girls in the modeling group were analyzed using univariate analysis, and binary logistic regression analysis was used to select independent influencing factors, and a nomogram model was constructed. The prediction model was validated by combining the existing validation group data. Results Univariate and multivariate logistic regression analyses indicated that bone age difference, LH baseline value, LH peak/FSH peak, and 25-(OH)D level were independent influencing factors for the occurrence of RP-CPP in girls (all P＜0.05). The established nomogram model was validated, and the calibration plot showed good performance of the prediction model. The area under the receiver operating characteristic (ROC) curve for the modeling group was 0.654, and for the validation group, it was 0.687, with good fit of the calibration curve (all P＜0.05). Conclusions Bone age difference, LH baseline value, LH peak/FSH peak, and 25-(OH)D level are independent influencing factors for the occurrence of RP-CPP in girls.

Key words

central precocious puberty / luteinizing hormone / follicle-stimulating hormone / bone age / serum 25-hydroxyvitamin D / predictive value

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LUO Yun, TAN Lilan, ZHANG Meng. Predictive value of bone age, luteinizing hormone/follicle-stimulating hormone ratio combined with serum 25-hydroxyvitamin D level for rapidly progressive central precocious puberty[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(10): 829-834

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