Bioinformatics-based analysis of the mechanism of Shaoma Zhijing granules in treating tourette syndrome

WANG Jiahuan; ZHONG Bo; WANG Xiaomin.

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Medical Journal of the Chinese People Armed Police Forces ›› 2025, Vol. 36 ›› Issue (11) : 970-977.

ORIGINAL ARTICLES

Bioinformatics-based analysis of the mechanism of Shaoma Zhijing granules in treating tourette syndrome

WANG Jiahuan¹, ZHONG Bo², WANG Xiaomin³.

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Abstract

Objective To explore the mechanism of Shaoma Zhijing granules (SMZJG) in treating tourette syndrome (TS) by using bioinformatics analysis methods. Methods Bioinformatics and molecular docking techniques were integrated to screen the active compounds and candidate targets, and the pathway enrichment analysis was performed to explain the mechanism of SMZJG against TS. Results A total of 92 pivotal targets were screened by bioinformatics analysis, suggesting their potential role in SMZJG’s therapeutic effect on TS. GO function analysis revealed that the therapeutic effect of SMZJG on TS was possibly associated with synaptic transmission and regulation of neuronal synaptic plasticity. KEGG analysis obtained multiple signaling pathways such as neuroactive ligand-receptor interaction, cAMP signaling pathway, and calcium signaling pathway. Molecular docking was carried out with 8 main active ingredients with corresponding TS-related targets. It was found that several ingredients, such as gastrodin, paeoniflorin and rhynchophylline, showed good affinity, suggesting a direct-action relationship with the known targets of TS. Conclusions Based on its pharmacological characteristics, SMZJG can exert a therapeutic effect on TS through the synergistic effect of multiple components and a complex network of interaction mechanisms among multi-targets and pathways.

Key words

Shaoma Zhijing granules / tourette syndrome / bioinformatics / molecular docking / mechanism of action

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WANG Jiahuan, ZHONG Bo, WANG Xiaomin.. Bioinformatics-based analysis of the mechanism of Shaoma Zhijing granules in treating tourette syndrome[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(11): 970-977

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