Effect of repeated transcranial magnetic stimulation on serum BDNF in elderly patients with mild cognitive impairment

QUAN Qingyun; WANG Xiaoyan; ZHANG Yu; LEI Zhuoyue

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Medical Journal of the Chinese People Armed Police Forces ›› 2025, Vol. 36 ›› Issue (3) : 205-207.

ORIGINAL ARTICLES

Effect of repeated transcranial magnetic stimulation on serum BDNF in elderly patients with mild cognitive impairment

QUAN Qingyun¹, WANG Xiaoyan¹, ZHANG Yu¹, LEI Zhuoyue²

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Abstract

Objective To observe the effect of repeated transcranial magnetic stimulation (rTMS) on serum brain-derived neurotrophic factor (BDNF) in elderly patients with mild cognitive impairment (MCI). Methods A total of 65 elderly patients with MCI who were admitted to Provincial Corps Hospital of Chinese People's Armed Police Force from January 2022 to October 2023 were included in the study, and divided into control group (n=32) and treatment group (n=33) by random number table method. In the control group,40mg of ginkgo biloba extract was taken orally (3 times/day) plus sham stimulation, while the treatment group received ginkgo biloba extract (manufacturer, specification, usage and dosage were the same as the control group) plus rTMS, and the primary disease was treated simultaneously in both groups. Serum BDNF was measured before treatment and 4 weeks after treatment, respectively, the clinical efficacy of the two groups before and after treatment was compared using the Simple Mental State Intelligence Scale (MMSE) and Montreal Cognitive Assessment Scale (MoCA) scores. Results After treatment, MMSE [(24.58±1.640) vs. (22.50±1.344)] and MoCA scores [(24.03±1.51) vs. (22.03±1.28)] in the treatment group were higher than those in the control group. MMSE [(24.58±1.64) vs. (22.97±1.78)] and MoCA [(24.03±1.51) vs. (21.88±1.75)] scores of the treatment group were significantly higher after treatment than those before treatment, and the differences were statistically significant (P＜0.05). After treatment, the serum BDNF level in the treatment group was significantly higher than that of the control group [(9.54±1.64) vs. (8.28±1.91)], and the serum BDNF level of the treatment group was higher than that before treatment [(9.54±1.64) vs. (7.93±1.62)], with statistically significant differences (P＜0.05). Conclusions Serum BDNF level is closely related to cognitive impairment in the elderly. rTMS therapy can increase the BDNF the level of BDNF in senile MCI patients and improve cognitive function, which is worthy of clinical promotion.

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repeated transcranial magnetic stimulation / the elderly / cognitive function / brain-derived neurotrophic factor

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QUAN Qingyun, WANG Xiaoyan, ZHANG Yu, LEI Zhuoyue. Effect of repeated transcranial magnetic stimulation on serum BDNF in elderly patients with mild cognitive impairment[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(3): 205-207

References

[1] Petersen R C.Clinical practice. Mild cognitive impairment[J].N Engl J Med,2011,364(23):2227-2234.
[2] 刘纽,熊信,薛亚奇.认知功能障碍:运动、孤独症和脑源性神经营养因子的相互作用[J].生物学杂志,2024,41(4):94-102.
[3] 吴毅.重复经颅磁刺激在脑卒中康复中的临床应用与作用机制的研究进展[J].中国康复医学杂,2023,38(2):147-150.
[4] 中国痴呆与认知障碍诊治指南写作组,中国医师协会神经内科医师分会认知障碍疾病专业委员会.2018中国痴呆与认知障碍诊治指南(五):轻度认知障碍的诊断与治疗[J].中华医学杂志,2018,98(17):1294-1301.
[5] Folstein M F, Folstein S E, McHugh P R. Minimental state.Apractical method for grading the cognitivestate of patients for theclinician[J].J Psychiatr Res,1975,12(3):189-198.
[6] Nasreddine Z S,Phillips N A,Bedlirian V,et al. The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment[J].J Am Geriatr Soc,2005,53(4):695-699.
[7] Song W, Du B, Xu Q, et al. Low-frequency transcranial magnetic stimulation for visual spatial neglect:a pilot study[J].J Rehabil Med,2009,41(3):162-165.
[8] 中国医师协会神经调控专业委员会电休克与神经刺激学组.重复经颅磁刺激治疗专家共识[J].转化医学杂志,2018,7(1):4-9.
[9] 袁梓健,郭立燕,张妍,等.中国老年人轻度认知障碍现状及其影响因素[J].济宁医学院学报,2022,45(3):183-188.
[10] Petersen R C.Mild cognitive impairment: transition between aging and alzheimer′s disease[J]. Neurologia,2000,15(3):93-101.
[11] Dodge H H, Zitzelberger T, Oken B S,et al.A randomized placebo-controlled trial of ginkgo biloba for the prevention of cognitive decline[J].Neurology,2008,70(19):1809-1817.
[12] 牛玉莲,王红星,王玉平.重复经颅磁刺激治疗抑郁症的研究进展[J].中华医学杂志,2017,97(31):2470-2472.
[13] 康杰,郭晓蕊,陈家久,等.难治性抑郁症的非药物治疗研究进展[J].武警医学,2018,29(10):990-994.
[14] Valero-Cabre A, Amengual J L, Stengel C,et al.Trancranial magnetic stimulation in basic and clinical neuroscience:a comprehensive review of fundamental principles and novel insights[J].Neurosci Biobehav Rev,2017,83(3):381-404.
[15] Giacomo K.Do studies on cortical plasticity provide a rationale or using non-invasive brain stimulation as a treatment for prakinson's disease patients[J].Front Neurol,2013,180(4):1-4.
[16] Wang F,Geng X,Tao H Y,et al.The restoration after repetitive transcranial magnetic stimulation treatment on cognitive ability of vascular dementia rats and its impacts on synaptic plasticity in hippocampal CA1 area[J].J Mol Neurosci,2010,41(1):145-155.
[17] Palasz E,Wysocka A,Gasiorowska A,et al.BDNF as a promising therapeutic agent in parkinson's disease[J]. Int J Mol Sci,2020,21(3):1170-1193.
[18] Rauti R,Cellot G,D'Andrea P,et al.BDNF impacton synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses[J].Mol Brain,2020,13(1):43-59.
[19] Wang M,Xie Y,Qin D.Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurode generative diseases[J].Brain Res Bull,2021,166,(1):172-184.
[20] 王玉香,崔传举,燕燕,等.阿尔茨海默病患者血清BDNF,IGF-1,UA,Hcy水平及其与认知功能损伤的关系[J].交通医学,2021,35(3):70-72.
[21] Kurozumi K,Nakamura K,Tamiya T,et al.BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model[J].Mol Ther,2004,9(2):189-197.
[22] 邢维昊,张婕,巫晓宇,等.脑源性神经营养因子与神经炎症在神经退行性疾病中的作用研究进展[J].中国医药科学,2022,12(10):21-24.
[23] 刘晋,赵敬堃,段淑荣,等.重复经颅磁刺激联合认知训练治疗脑卒中后认知障碍的疗效观察[J].神经损伤与功能重建,2019,14(1):11-14,18.