Value of preoperative inflammatory biomarkers in predicting long-term prognosis of lung adenocarcinoma patients after microwave ablation

LIU Mengjie; FU Yili; WANG Jing; CUI Songping; ZHAO Qing; CHANG Xiner

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Medical Journal of the Chinese People Armed Police Forces ›› 2025, Vol. 36 ›› Issue (3) : 208-212.

Value of preoperative inflammatory biomarkers in predicting long-term prognosis of lung adenocarcinoma patients after microwave ablation

LIU Mengjie¹, FU Yili², WANG Jing², CUI Songping², ZHAO Qing², CHANG Xiner¹

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Abstract

Objective To explore the value of preoperative inflammatory biomarkers in predicting the long-term prognosis of patients with lung adenocarcinoma after Microwave Ablation (MWA). Methods Patients with early-stage lung adenocarcinoma patients who underwent MWA at Beijing Chao-Yang Hospital from January 2012 to June 2021 were included. The area under the curve (AUC) of the receiver's operating characteristic (ROC) curve was used to assess the predictive value of inflammatory biomarkers. Multivariate Cox risk analysis was used to explore the effectiveness of inflammatory biomarkers in predicting outcomes. Results A total of 143 patients were enrolled. The AUC of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI) for overall survival (OS) were 0.787, 0.731, 0.725, 0.780, and 0.802, respectively. The AUC of NLR, PLR, MLR, SII, and SIRI for disease-free survival (DFS) were 0.700, 0.623, 0.556, 0.718, and 0.668, respectively. Cox risk analysis showed that high SII was independently associated with low OS (OR=1.066, P=0.019) and low DFS (OR=1.068, P=0.016). Kaplan-Meier survival analysis revealed that patients with high preoperative SII had significantly worse prognosis (P<0.001). Conclusions Preoperative SII is an effective marker in predicting the long-term prognosis of early-stage lung adenocarcinoma patients after MWA. Other risk factors also include tumor size, degree of differentiation and smoking status.

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lung adenocarcinoma / microwave ablation / biomarker / systemic immune inflammation index / systemic inflammation response index

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LIU Mengjie, FU Yili, WANG Jing, CUI Songping, ZHAO Qing, CHANG Xiner. Value of preoperative inflammatory biomarkers in predicting long-term prognosis of lung adenocarcinoma patients after microwave ablation[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(3): 208-212

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