Diagnostic value of L3 skeletal muscle index in the progression of pancreatitis

CHENG Fubin; YANG Xianwen; LI Long

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Medical Journal of the Chinese People Armed Police Forces ›› 2025, Vol. 36 ›› Issue (3) : 214-218.

ORIGINAL ARTICLES

Diagnostic value of L₃ skeletal muscle index in the progression of pancreatitis

CHENG Fubin¹, YANG Xianwen², LI Long³

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Abstract

Objective To investigate the application value of L₃ skeletal muscle index (L₃SMI) in the progression of pancreatitis. Methods A total of 146 patients with pancreatitis and 143 healthy people from August 2020 to August 2023 at Guangdong Provincial Corps Hospital of Chinese People's Armed Police Force were included in this study. All participants underwent CT examination to determine L₃SMI. Serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-C chemokine ligand 2 (CCL2) and leptin were measured by enzyme-linked immunosorbent assay(ELISA), and a four-element linear regression model was established to exclude possible confounding factors. Results After adjusting the model, the L₃SMI index showed a significant decreasing trend in the control group, first-time pancreatitis(FAP) group, recurrent acute pancreatitis(RAP) group, and chronic pancreatitis(CP) group (p-trends of 0.005, 0.019, and 0.020, respectively). Leptin was significantly negatively correlated with L₃SMI in all models (Model 1: β=-0.005, P=0.021; Model 2: β=-0.004,P=0.044; Model 3: β=-0.003, P=0.063; Model4: β=-0.004, P=0.054). There was no significant correlation between other factors and L₃SMI. Conclusions L₃SMI decreases gradually during the continuous process from FAP to RAP and CP, and the changes of leptin level may be an important influencing factor.

Key words

L₃ skeletal muscle index / pancreatitis / leptin

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CHENG Fubin, YANG Xianwen, LI Long. Diagnostic value of L₃ skeletal muscle index in the progression of pancreatitis[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(3): 214-218

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