Objective To compare the effects of ciprofol and propofol on hemodynamics and postoperative adverse events during oral catheterization and enteroscopy. Methods A total of 180 patients who underwent endotracheal intubation and enteroscopy under general anesthesia at Characteristics Medical Center of PLA Air Force from December 2023 to September 2024 were enrolled in this study and randomly divided into ciprofol group (group C) and propofol group (group P), with 90 cases in each group. Group C received ciprofol during induction and maintenances, while group P received propofol to maintain sedation. This study recorded the hemodynamic indexes before anesthesia induction (T0), 2min after anesthesia induction (T1), at enteroscopy entry (T2), 30min after anesthesia administration (T3), at the end of surgery (T4), and at extubation (T5), the use of vasoactive drugs during surgery, anesthesia related adverse events, recovery time, extubation time and other key indicators. Results At T1 and T2 time points, the systolic blood pressure and diastolic blood pressure in group C were higher than those in group P (P<0.05), the incidence and total times and total times of hypotension in group C were lower than those in group P (P<0.05), and the times and dosage of vasoactive drugs in group C were also significantly lower than those in group P (P<0.05). The incidence of injection pain, nausea, vomiting, and abdominal distension in group C was significantly lower than in group P (P<0.05). The recovery time and extubation time for group C were longer than those in group P (P<0.001). Conclusions Compared with propofol, ciprofol anesthesia can maintain hemodynamic stability more effectively and reduce the incidence of postoperative gastrointestinal adverse reactions during painless enteroscopy.
Key words
painless enteroscopy /
ciprofol /
propofol /
general anesthesia induction /
general anesthesia maintenance
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