Observation on curative effect of cognitive therapy combined with physical exercise in patients with mild cognitive impairment

ZHANG Wei; LI Xinyu; LI Haitao; ZHANG Xiao; GUO Fang

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Medical Journal of the Chinese People Armed Police Forces ›› 2025, Vol. 36 ›› Issue (4) : 333-336.

Observation on curative effect of cognitive therapy combined with physical exercise in patients with mild cognitive impairment

ZHANG Wei¹, LI Xinyu², LI Haitao¹, ZHANG Xiao¹, GUO Fang¹

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Abstract

Objective To explore the clinical efficacy of combined intervention of exercise and cognition in patients with mild cognitive impairment (MCI). Methods A total of 63 patients with MCI were randomly divided into a study group (n=31) and a control group (n=32). Both groups received general treatment, and the study group received combined training of exercise and cognition for 12 weeks. The Montreal Cognitive Assessment Scale (MoCA) was assessed before and after the training and 12 weeks after the training was stopped. Results There was no statistical difference in MoCA scores between the two groups before treatment. After the end of combined cognitive motor training and 12 weeks after stopping training, the MoCA scores of the study group were higher than those of the control group, with statistical significance (P<0.05). The improvement of cognitive function in the study group was mainly manifested in visuospatial/executive function, attention, language and memory. Conclusions Combined intervention of exercise and cognition can improve the cognitive function of patients with MCI, and has a certain lasting effect.

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cognitive therapy / exercise therapy / mild cognitive impairment

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ZHANG Wei, LI Xinyu, LI Haitao, ZHANG Xiao, GUO Fang. Observation on curative effect of cognitive therapy combined with physical exercise in patients with mild cognitive impairment[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(4): 333-336

References

[1] Lindbergh C A, Dishman R K, Miller L S. Functional disability in mild cognitive impairment: a systematic review andmeta-analysis[J]. Neuropsychology Review, 2016, 26(2):129-159.
[2] Mariani E, Monastero R, Mecocci P. Mild cognitive impairment: a systematic review [J]. J Alzheimers Dis, 2007,12: 23-35.
[3] Jia L, Du Y, Chu L, et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study[J]. Lancet Public Health, 2020,5(12): e661-e671.
[4] Salzman T, Sarquis-adamson Y, Son S, et al. Associations of multidomain interventions with improvements in cognition in mildcognitive impairment: a systematic review and meta-analysis[J].JAMA Netw Open, 2022, 5(5): e226744.
[5] Albert M S, DeKosky S T, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J]. Alzheimers Dement, 2011, 7(3):270-279.
[6] Bai W, Chen P, Cai H, et al. Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: a meta-analysis and systematic review of epidemiology studies[J]. Age Ageing, 2022, 51(8):1-14.
[7] David A R, Pradyumna K B, Lauren A N, et al. Effects of simultaneous cognitive and aerobic exercise training on dual-task walking performance in healthy older adults: results from a pilot randomized controlled trial[J]. BMC Geriatr, 2020,20(1):83-93.
[8] You J H, Shetty A, Jones T, et al. Effects of dual-task cognitive-gait intervention on memory and gait dynamics in older adults with a history of falls: a preliminary investigation[J]. Neurorehabilitation, 2009, 24(2):193-8.
[9] Train the Brain Consortium. Randomized trial on the effects of acombined physical/cognitive training in aged MCI subjects:the train the Brain study[J]. Sci Rep,2017,7:39471.
[10] Karssemeijer E G A,Aaronson J A,Bossers W J,et al. Positive effects of combined cognitive and physical exercisetraining on cognitive function in older adults with mild cogni-tive impairment or dementia:a meta-analysis[J]. Ageing ResRev,2017,40(1):75-83.
[11] Migueles J H, Cadenas S C, Esteban C I, et al. Associations of objectively-assessed physical activity and sedentary time with hippocampal gray matter volume inchildren with overweight/obesity[J]. J Clin Med, 2020,9(4):1080.
[12] Leavitt V M, Cirnigliaro C, Cohen A, et al. Aerobic exercise increases hippocampal volumeand improves memory in multiple sclerosis: preliminary findings[J]. Neurocase,2014,20(6):695-697.
[13] Song D, Yu D S F, Li P W C, et al. The effectiveness of physical exercise on cognitive and psychological outcomes in individuals with mild cognitive impairment: a systematic review and meta-analysis[J]. Int J Nurs Stud, 2018, 79:155-164.
[14] Zotcheva E, Bergh S, Selbæk G, et al. Midlife physical activity, psychological distress, and dementia risk: the HUNT Study[J]. J Alzheimer Dis, 2018, 66(2): 825-833.
[15] Siu M Y, Lee D T F. Effects of Tai Chi on cognition and instrumental activities of daily living in community dwelling older people with mild cognitive impairment[J]. BMC Geriatrics, 2018,18(1):37.
[16] Miller S M, Taylor P R E. Effects of Tai Chi on cognitive function in communitydwelling older adults:a review[J]. Geriatric Nursing, 2014,35(1):9-19.