Effects of isolated diastolic hypertension in young patients on carotid intima-media thickness and vascular endothelial function

YANG Xiaolin; SU Rui; XU Dawei; ZHAO Zaixian; ZHAO Haiyan

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Medical Journal of the Chinese People Armed Police Forces ›› 2025, Vol. 36 ›› Issue (6) : 471-474.

Effects of isolated diastolic hypertension in young patients on carotid intima-media thickness and vascular endothelial function

YANG Xiaolin¹, SU Rui¹, XU Dawei², ZHAO Zaixian³, ZHAO Haiyan²

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Abstract

Objective To investigate the effects of isolated diastolic hypertension （IDH） on the structure of the carotid artery and endothelial function in young patients. Methods Physical examination data in 2021 were collected from Beijing Municipal Corps Hospital of Chinese People’s Armed Police Force. The carotid intima-media thickness （CIMT） and endothelin-1 （ET-1） of IDH patients and healthy controls were compared,and the association between the them and the changes in diastolic blood pressure was explored. Results The CIMT of IDH patients was higher than that of healthy controls [（0.84±0.11）vs.（0.75±0.10）,P=0.030], and the ET-1 level also showed an increase[（116.63.15±20.84）vs.（103.21±23.88）, P=0.042]. At the same time, there was a positive correlation between CIMT and ET-1 （R²=0.61, P < 0.001）. Conclusions The increase in diastolic blood pressure has a negative impact on the structure and function of carotid artery to a certain extent. It is necessary to strengthen the popularization of health knowledge about IDH and early intervention.

Key words

isolated diastolic hypertension / carotid intima-media thickness / vascular endothelial function / young men

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YANG Xiaolin, SU Rui, XU Dawei, ZHAO Zaixian, ZHAO Haiyan. Effects of isolated diastolic hypertension in young patients on carotid intima-media thickness and vascular endothelial function[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(6): 471-474

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