Objective To investigate the efficacy and safety of percutaneous vertebroplasty in the treatment of osteoporotic vertebral compression fractures under different surgical timing. Methods Comprehensive search was conducted in both Chinese and English databases such as VIP Chinese Journal Service Platform, China National Knowledge Infrastructure （CNKI）, Wanfang Medical Network, PubMed, Embase, Scopus, and Web of Science. The efficacy differences of vertebroplasty in patients at the acute, subacute, and chronic stages were compared. Mean differences （MDs） and risk differences （RDs） were employed as combined variables,and 95% was selected as the confidence interval （CI）. Results A total of 9 clinical studies were included, involving 678 patients. The findings showed that early percutaneous vertebroplasty could reduce the incidence of postoperative vertebral refracture compared with delayed surgery（RD：-0.13;95%CI：-0.21~-0.05;P=0.002）, and had more advantages in postoperative Cobb angle recovery（MD: -5.96; 95%CI：-11.78~ -0.14;P=0.04）,while the volume of injected vertebral bone cement in delayed surgery was notably lower（MD: 1.24; 95% CI： 0.57 ~ 1.91;P=0.0003）. There were no significant differences between the two groups regarding postoperative bone cement leakage,VAS scores,and ODI indices. Conclusions In the treatment of osteoporotic vertebral compression fractures,early percutaneous vertebroplasty can effectively decrease the incidence of postoperative vertebral refracture and achieve better postoperative Cobb angle, although the amount of bone cement injection is smaller after delayed surgery.
Key words
percutaneous vertebroplasty /
surgical timing /
osteoporotic vertebral compression fracture /
Meta-analysis
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