Relationship between gingival crevicular fluid Gal-3, asprosin and prognosis of patients with periimplantitis

FENG Lina; FAN Zhuojie

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Medical Journal of the Chinese People Armed Police Forces ›› 2025, Vol. 36 ›› Issue (6) : 505-510.

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Relationship between gingival crevicular fluid Gal-3, asprosin and prognosis of patients with periimplantitis

FENG Lina, FAN Zhuojie

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Abstract

Objective To investigate the relationship between gingival crevicular fluid galectin-3 (Gal-3), asprosin and prognosis of patients with periimplantitis (PI). Methods A total of 138 patients with PI admitted to the Third Medical Center of PLA General Hospital from January 2021 to December 2023 were selected as the disease group, and were divided into a poor group (44 cases) and a good group (94 cases) according to their prognosis. Another 138 healthy implant patients were selected as a control group. The levels of Gal-3 and asprosin in gingival crevicular fluid were compared. The correlation between the levels of Gal-3 and asprosin in gingival crevicular fluid and periodontal clinical indicators was analyzed using Pearson’s method. Multivariate logistic regression was applied to analyze the influencing factors of poor prognosis in PI patients. ROC curve was used to analyze the predictive value of gingival crevicular fluid Gal-3 and asprosin levels combined with periodontal clinical indicators for poor prognosis in PI patients. Results Compared with control group, the levels of Gal-3 and asprosin in gingival crevicular fluid and periodontal clinical indicators in the disease group were significantly increased (P<0.05).The levels of Gal-3 and asprosin in gingival crevicular fluid were positively correlated with periodontal clinical indicators (P<0.05). Compared with the good group, the levels of Gal-3 and asprosin and periodontal clinical indicators were greatly higher in the poor group (P<0.05). The area under the curve (AUC) of Gal-3, asprosin levels, PD, mGI, and mSBI combined in predicting poor prognosis in PI patients was significantly higher than that predicted by a single indicator (Z combined prediction-Gal-3=2.892, Z combined prediction- sprosin=2.062, Z combined prediction- PD=2.710, Z combined prediction- mGI=2.929, Z combined prediction- mSBI=3.017, P=0.004, 0.039, 0.007, 0.003, 0.003). Conclusions Gingival crevicular fluid Gal-3 and asprosin levels combined with periodontal clinical indicators have high predictive value for poor prognosis in PI patients.

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periimplantitis / galectin-3 / asprosin / periodontal clinical indicators

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FENG Lina, FAN Zhuojie. Relationship between gingival crevicular fluid Gal-3, asprosin and prognosis of patients with periimplantitis[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(6): 505-510

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