Research progress on the relationship between oxidative stress, autophagy and periodontitis

XIANG Yulan, LUAN Yingyi, ZHANG Dongliang

Medical Journal of the Chinese People Armed Police Forces ›› 2025, Vol. 36 ›› Issue (6) : 535-538.

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Medical Journal of the Chinese People Armed Police Forces ›› 2025, Vol. 36 ›› Issue (6) : 535-538.
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Research progress on the relationship between oxidative stress, autophagy and periodontitis

  • XIANG Yulan, LUAN Yingyi, ZHANG Dongliang
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XIANG Yulan, LUAN Yingyi, ZHANG Dongliang. Research progress on the relationship between oxidative stress, autophagy and periodontitis[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(6): 535-538

References

[1] Sulijaya B, Takahashi N, Yamazaki K.Host modulation therapy using anti-inflammatory and antioxidant agents in periodontitis: a review to a clinical translation[J]. Arch Oral Biol, 2019, 105:72-80.
[2] Kowalski J, Nowak M, Górski B, et al. What has immunology brought to periodontal disease in recent years?[J]. Arch Immunol Ther Exp (Warsz), 2022, 70(1):26.
[3] Sczepanik F S C, Grossi M L, Casati M, et al. Periodontitis is an inflammatory disease of oxidative stress: we should treat it that way[J]. Periodontology 2000, 2020, 84(1):45-68.
[4] Jiang W, Wang Y, Cao Z, et al. The role of mitochondrial dysfunction in periodontitis:from mechanisms to therapeutic strategy[J]. J Periodontal Res, 2023, 58(5):853-863.
[5] Greabu M, Giampieri F, Imre M M, et al. Autophagy, one of the main steps in periodontitis pathogenesis and evolution[J]. Molecules, 2020, 25(18):4338.
[6] Díaz C M, Bullon B, Ruiz-Salmerón R J, et al. Molecular inflammation and oxidative stress are shared mechanisms involved in both myocardial infarction and periodontitis[J]. J Periodontal Res, 2020, 55(4):519-528.
[7] Yu B, Wang C-Y.Osteoporosis and periodontal diseases - an update on their association and mechanistic links[J]. Periodontology 2000, 2022, 89(1):99-113.
[8] Peña-Oyarzún D, San Martin C, Hernández-Cáceres MP, et al. Autophagy in aging-related oral diseases[J]. Front Endocrinol (Lausanne), 2022, 13:903836.
[9] Liu J, Wang X, Zheng M, et al. Abnormal mitochondrial structure and function are retained in gingival tissues and human gingival fibroblasts from patients with chronic periodontitis[J]. J Periodontal Res, 2022, 57(1):94-103.
[10] Lorenzo-Pouso A I, Castelo-Baz P, Pérez-Sayáns M, et al. Autophagy in periodontal disease: evidence from a literature review[J]. Arch Oral Biol, 2019, 102:55-64.
[11] Lee H A, Park M H, Song Y, et al. Role of aggregatibacter actinomycetemcomitans-induced autophagy in inflammatory response[J]. J Periodontol, 2020, 91(12):1682-1693.
[12] Zhu C, Zhao Y, Pei D, et al. PINK1 mediated mitophagy attenuates early apoptosis of gingival epithelial cells induced by high glucose[J]. BMC Oral Health, 2022, 22(1):144.
[13] Kim W J, Park S Y, Kim O S, et al. Autophagy upregulates inflammatory cytokines in gingival tissue of patients with periodontitis and lipopolysaccharide-stimulated human gingival fibroblasts[J]. J Periodontol, 2022, 93(3):380-391.
[14] Liu M, Shao J, Zhao Y, et al. Porphyromonas gingivalis evades immune clearance by regulating lysosome efflux[J]. J Dent Res, 2023, 102(5):555-564.
[15] Lee K, Roberts J S, Choi C H, et al. Porphyromonas gingivalis traffics into endoplasmic reticulum-rich-autophagosomes for successful survival in human gingival epithelial cells[J]. Virulence, 2018, 9(1):845-859.
[16] Meghil M M, Tawfik O K, Elashiry M, et al. Disruption of immune homeostasis in human dendritic cells via regulation of autophagy and apoptosis by porphyromonas gingivalis[J]. Front Immunol, 2019, 10:2286.
[17] Chen L, Yang Y, Bao J, et al. Autophagy negative-regulating Wnt signaling enhanced inflammatory osteoclastogenesis from pre-OCs in vitro[J]. Biomed Pharmacother, 2020, 126: 110093.
[18] Gou H, Chen X, Zhu X, Li L, et al. Sequestered SQSTM1/p62 crosstalk with keap1/NRF2 axis in hPDLCs promotes oxidative stress injury induced by periodontitis[J]. Free Radic Biol Med, 2022, 190:62-74.
[19] Sufaru I-G, Teslaru S, Pasarin L, et al. Host response modulation therapy in the diabetes mellitus—periodontitis conjuncture: a narrative review[J]. Pharmaceutics, 2022, 14(8):1728.
[20] Iova G M, Calniceanu H, Popa A, et al. The antioxidant effect of curcumin and rutin on oxidative stress biomarkers in experimentally induced periodontitis in hyperglycemic wistar rats[J]. Molecules, 2021, 26(5):1332.
[21] Corrêa M G, Absy S, Tenenbaum H, et al. Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation[J]. J Periodontal Res, 2019, 54(3):225-232.
[22] López-Valverde N, Pardal-Peláez B, López-Valverde A, et al. Effectiveness of propolis in the treatment of periodontal disease: updated systematic review with meta-analysis[J]. Antioxidants, 2021, 10(2):269.
[23] Song Y, Chung J.Zingerone-induced autophagy suppresses IL-1β production by increasing the intracellular killing of aggregatibacter actinomycetemcomitans in THP-1 macrophages[J]. Biomedicines, 2023, 11(8):2130.
[24] Yuan W, Huang M, Wu Y, Liu J, ,et al. Agaricus blazei murrill polysaccharide attenuates periodontitis via H2S/NRF2 axis-boosted appropriate level of autophagy in PDLCs[J]. Mol Nutr Food Res. Agaricus blazei murrill polysaccharide attenuates periodontitis via H2S/NRF2 axis-boosted appropriate level of autophagy in PDLCs[J]. Mol Nutr Food Res, 2023, n/a(n/a):2300112.
[25] Karaca B, Yilmaz M, Gursoy U K.Targeting nrf2 with probiotics and postbiotics in the treatment of periodontitis[J]. Biomolecules, 2022, 12(5):729.
[26] Ying S, Tan M, Feng G, et al. Low-intensity pulsed ultrasound regulates alveolar bone homeostasis in experimental periodontitis by diminishing oxidative stress[J]. Theranostics, 2020, 10(21):9789-9807.
[27] Jian Z, Li Y, Zhang C, et al. Low-intensity pulsed ultrasound attenuates periodontal ligament cells apoptosis by activating yes-associated protein-regulated autophagy[J]. Ultrasound Med Biol, 2023, 49(5):1227-1237.
[28] Mooney E C, Sahingur S E.The ubiquitin system and A20: implications in health and disease[J]. J Dent Res, 2020, 100(1):10-20.
[29] Li X, Zhao Y, Peng H, et al. Robust intervention for oxidative stress-induced injury in periodontitis via controllably released nanoparticles that regulate the ROS-PINK1-Parkin pathway[J]. Front Bioeng Biotechnol, 2022, 10:1081977.
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