Objective To investigate the effects of traditional Chinese medicine's fivetone therapy combined with medication on depressive mood and heart rate variability (HRV) indicators in patients with major depressive disorder (MDD). Methods A total of 64 male MDD patients treated at a military hospital between July and October 2024 were were selected and randomly divided into a control group (n=32) and an experimental group (n=32) at a ratio of 1:1. The control group received standard antidepressant pharmacotherapy, including SSRIs, SNRIs, and benzodiazepine drugs, once a day for 4 weeks, while the experimental group received traditional Chinese medicine's fivetone therapy in addition to the standard pharmacotherapy (30-40 min /session,5 sessions/week for 4 weeks). Both groups were assessed using the Hamilton Depression Rating Scale (HAMD) and Patient After treatment, the HAMD scores and PHQ9 scores of both groups were better than those before treatment, with statistically significant differences (P<0.05).The experimental group demonstrated significantly lower HAMD scores (6.29 ± 4.13 vs. 9.77 ± 7.31; P<0.05) and PHQ9 scores (3.32 ± 2.51 vs. 5.87 ± 5.32; P<0.05) compared to the control group , with statistically significant differences (P<0.05). The timedomain indicators of HRV in the experimental group were better than those of the control group [SDNN (81.32 ± 31.64 vs. 66.72 ± 28.58), RMSSD (104.14 ± 68.19 vs. 57.63 ± 34.26), PNN50 (25.48 ± 18.02 vs. 16.64 ± 12.7）], and the frequencydomain indicators were also better than those of the control group [TP (361.24 ± 201.85 vs. 684.81 ± 404.84), HF (91.85± 111.52 vs. 145.60 ± 125.79), LF (291.75 ± 129.65 vs. 194.87 ± 90.65), LF/HF ratio (3.25 ± 2.33 vs.7.97 ± 6.41）], with statistically significant differences (P<0.05). Conclusions Traditional Chinese medicine's fivetone therapy combined with antidepressant pharmacotherapy can effectively alleviates depressive mood and improve HRV indicators, and it is relatively safe.
Key words
traditional Chinese medicine's fivetone therapy /
depression /
heart rate variability /
antidepressant pharmacotherapy /
Hamilton Depression Rating Scale
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