Therapeutic effects of Yupingfeng granules combined with diphenhydramine attached umbilical in children with atopic dermatitis

WEI Junru; XUN Yingjing; HE Xin; LU Yiping; DUAN Feng

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Medical Journal of the Chinese People Armed Police Forces ›› 2025, Vol. 36 ›› Issue (8) : 650-653.

WEI Junru, XUN Yingjing, HE Xin, LU Yiping, DUAN Feng

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Abstract

Objective To investigate the therapeutic effects of Yupingfeng granule combined with diphenhydramine attached umbilical in children with atopic dermatitis（AD）. Methods A total of 200 pediatric patients diagnosed with AD in Henan Provincial Corps Hospital of Chinese People’s Armed Police Force from March 2022 to May 2024 were randomly divided into two groups, with 100 cases in each group. The control group was given conventional treatment, while the treatment group was treated with Yupingfeng granules combined with diphenhydramine attached umbilical on the basis of the control group. The clinical efficacy,diphenhydramine on eosinophils（EOS）, vitamin D levels and adverse reactions before and after treatment were compared between the two groups. Results After treatment,the Eczema Area and Severity Index （EASI） and Scoring Atopic Dermatitis （SCORAD） scores markedly decreased in the treatment group versus the control group （P<0.05）.EOS level of the treatment group was significantly lower than that of the control group, and the vitamin D level was significantly higher than that of the control group（P<0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups （P > 0.05）; the total effective rate of clinical efficacy in the treatment group was higher than that in the control group（97.00 % vs. 82.00%; P<0.05）. Conclusions Yupingfeng feng granules combined with diphenhydramine attached umbilical can reduce EOS level,increase vitamin D level and improve clinical efficacy in children with AD patients, with high safety.

Key words

Yupingfeng granules / diphenhydramine attached umbilical / atopic dermatitis / eosinophils / vitamin D

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WEI Junru, XUN Yingjing, HE Xin, LU Yiping, DUAN Feng. Therapeutic effects of Yupingfeng granules combined with diphenhydramine attached umbilical in children with atopic dermatitis[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(8): 650-653

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