Objective To explore the influencing factors of acute exacerbation in elderly patients with chronic obstructive pulmonary disease (COPD). Methods A total of 102 elderly patients with acute exacerbation of COPD (AECOPD) treated at Beijing Municipal Corps Hospital of Chinese People’s Armed Police Force from January 2017 to December 2024 were retrospectively selected as the AECOPD group. Meanwhile, 100 patients without AECOPD were randomly selected as the COPD stable group. General data, blood routine test indicators, infection indicators [serum procalcitonin (PCT), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), white blood cell count, lymphocyte count, neutrophil/lymphocyte ratio (NLR), eosinophil count (EOS) levels], blood biochemical indicators [fasting blood glucose (FPG), HDL-C, LDL-C, TG, TC, Lac)] D-dimer (D-D), heart failure indicator serum N-terminal pro brain natriuretic peptide (NT proBNP), and blood gas analysis indicators (pH value, Lac) were compared between the two groups., and multivariate binary logistic regression analysis were used to explore the related factors of AECOPD occurrence. Results The proportion of community-acquired pneumonia, NT proBNP, hs-CRP, TNF-α, D-D, NLR, EOS, Lac, PCT, and IL-6 in the AECOPD group were higher than those in the COPD stable group (P＜0.05). The results of multivariate logistic regression analysis indicated that NT proBNP, hs-CRP, TNF-α, D-D were associated with the occurrence of AECOPD (P＜0.05), and hs CRP and TNF-α were independent influencing factors of AECOPD (P＜0.05). Conclusions The proportion of community-acquired pneumonia, NT proBNP, hs-CRP, TNF-α, D-dimer, NLR, EOS, Lac, PCT, IL-6 in AECOPD patients are significantly elevated, and NT proBNP, hs-CRP, TN-α and D-D are independently correlated with the occurrence of AECOPD, providing a reference basis for the prevention and treatment of COPD progression and improvement of prognosis.
Key words
chronic obstructive pulmonary disease /
acute exacerbation period /
hypersensitive c-reactive protein /
tumor necrosis factor-α /
D-dimer /
N-terminal B-type brain natriuretic peptide precursor
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