Value of the ratio of systemic immune-inflammation index to serum albumin in judging the severity of acute biliary pancreatitis

LIU Wei; YANG Liusheng; SUN Dengqun; NIU Zhihui; SUN Yanjun

PDF(1048 KB)

Medical Journal of the Chinese People Armed Police Forces ›› 2025, Vol. 36 ›› Issue (9) : 778-781.

Value of the ratio of systemic immune-inflammation index to serum albumin in judging the severity of acute biliary pancreatitis

LIU Wei¹, YANG Liusheng², SUN Dengqun², NIU Zhihui¹, SUN Yanjun²

Author information +

History +

Abstract

Objective To explore the value of the ratio of systemic immune-inflammation index (SII) to serum albumin (ALB) in judging the severity of acute biliary pancreatitis (ABP). Methods A retrospective analysis was conducted on 136 patients with ABP admitted to the General Surgery Department of Anhui Provincial Corps Hospital from January 2022 to December 2024. The patients were divided into non-severe (n=98) and severe (n=38) groups according to the revised Atlanta criteria. Blood samples collected within 24 hours of admission were analyzed for routine and biochemical parameters. The SII/ALB ratio, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and bedside index for severity in acute pancreatitis (BISAP) score were calculated. Receiver operating characteristic (ROC) curves were used to compare the diagnostic performance of these indicators. Results The severe group exhibited significantly higher SII/ALB, NLR, PLR, and BISAP scores than the non-severe group (P＜0.05). The ROC curve demonstrated that SII/ALB (AUC=0.804, 95% CI=0.727-0.882) and BISAP (AUC=0.806, 95% CI=0.731-0.881) had similar efficacy in judging the severity of ABP, and were superior to NLR (AUC=0.775, 95% CI=0.693-0.856) and PLR (AUC=0.643, 95% CI=0.540-0.746). Conclusions The SII/ALB ratio can be used as an effective indicator for early judgment of the severity of ABP and has high clinical application value.

Key words

systemic immune-inflammation index / serum albumin / acute biliary pancreatitis / disease severity

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

LIU Wei, YANG Liusheng, SUN Dengqun, NIU Zhihui, SUN Yanjun. Value of the ratio of systemic immune-inflammation index to serum albumin in judging the severity of acute biliary pancreatitis[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(9): 778-781

References

[1] 侯建根, 张艳花, 孙焕宏, 等. 急性胆源性胰腺炎LC＋LCBDE与LC＋ERCP/EST治疗的对比研究[J]. 中华肝胆外科杂志, 2024, 30(3):202-206.
[2] 姬红波, 王强, 白瑞锋, 等. 内镜下逆行胆胰管造影术术后柴芩承气汤辅助治疗重症急性胆源性胰腺炎的临床疗效与安全性研究[J]. 海南医学, 2025, 36(5):653-658.
[3] 苗利辉, 宋青, 刘辉, 等. 白细胞介素-6对重症急性胰腺炎早期判别预后的作用研究[J]. 中华危重病急救医学, 2013, 25(4):238-241.
[4] 赵成思, 姚维杰, 王佐正, 等. 急性胆源性胰腺炎患者胰液、胆汁中细菌、真菌分布特点及临床意义[J]. 中华肝胆外科杂志, 2022, 28(10):740-746.
[5] 刘东全, 胡金龙, 李敏, 等. 简易PICS评分在评价急性胰腺炎严重程度中的价值[J]. 重庆医学, 2021, 50(11):1852-1856, 1861.
[6] 郑云, 涂倩倩, 张阿芳, 等. 重症急性胰腺炎并发持续炎症-免疫抑制-分解代谢综合征的列线图预测模型构建与验证[J]. 中国急救医学, 2024, 44(10):890-896.
[7] Banks P A, Bollen T L, Dervenis C, et al. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus[J]. Gut, 2013, 62(1):102-111.
[8] Prasanth J, Prasad M, Mahapatra S J, et al. Early versus delayed cholecystectomy for acute biliary pancreatitis: a systematic review and Meta-analysis[J]. World J Surg, 2022, 46(6):1359-1375.
[9] 王永, 陈晨, 李永波. 双镜联合治疗急性胆源性胰腺炎合并胆囊结石的临床疗效[J]. 中国内镜杂志, 2024, 30(4):59-65.
[10] Chadda K R, Puthucheary Z. Persistent inflammation, immunosuppression, and catabolism syndrome (PICS): a review of definitions, potential therapies, and research priorities[J]. Br J Anaesth, 2024, 132(3):507-518.
[11] Chadda K R, Blakey E E, Davies T W, et al. Risk factors, biomarkers, and mechanisms for persistent inflammation, immunosuppression, and catabolism syndrome (PICS): a systematic review and meta-analysis[J]. Br J Anaesth, 2024, 133(3):538-549.
[12] Nakanishi N, Liu K, Hatakeyama J, et al. Post-intensive care syndrome follow-up system after hospital discharge: a narrative review[J]. J Intensive Care, 2024, 12(1):2.
[13] Bhatia M, Neoptolemos J P, Slavin J. Inflammatory mediators as therapeutic targets in acute pancreatitis[J]. Curr Opin Investig Drugs, 2001, 2(4):496-501.
[14] 崔军利, 尹华强, 倪培源, 等. SIRI、SII及HCAR联合检测对重症急性胰腺炎患者并发感染性胰腺坏死的评估价值[J]. 分子诊断与治疗杂志, 2024, 16(9):1631-1634.
[15] Koutroumpakis E, Wu B U, Bakker O J, et al. Admission hematocrit and rise in blood urea nitrogen at 24 h outperform other laboratory markers in predicting persistent organ failure and pancreatic necrosis in acute pancreatitis: a post hoc analysis of three large prospective databases[J]. Am J Gastroenterol, 2015, 110(12):1707-1716.