Objective To explore the correlation between immune function, coagulation function indicators and spinal mobility in patients with ankylosing spondylitis (AS). Methods A total of 150 AS patients who visited Characteristics Medical Center of Chinese People’s Armed Police Force from November 2019 to November 2024 were selected and divided into an active stage group and a stable stage group according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). The levels of indicators related with coagulation and fibrinolytic activity, platelet count (PLT), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), factors related with thrombosis, Th17/Treg and related factors, and oxidative stress indicators were compared between the two groups. The correlations between BASDAI, Bath Ankylosing spondylitis Functional Index (BASFI) and the above indicators was analyzed. Results Compared with the stable stage group, the levels of fibrinogen (FIB), D-dimer, PLT, fibrin degradation products (FDP), thrombin A2 (TXA2), plasminogen activator inhibitor (PAI), ESR, CRP, Th17, Th17/Treg, interleukin (IL)-17, IL-23 and malondialdehyde (MDA)were higher in the active stage group, while the levels of activated partial thromboplastin time (APTT), prostacyclin (PGI2), Treg, IL-10, transforming growth factor -β (TGF-β), superoxide dismutase (SOD), and catalase (CAT) were lower (P<0.05); Correlation analysis showed that BASDAI and BASFI in AS patients were positively correlated with D-dimer, PLT, FDP, TXA2, PAI, ESR, CRP, Th17, Th17/Treg, IL-17, IL-23, and MDA, and negatively correlated with APTT, PGI2, Treg, IL-10, TGF-β, SOD and CAT (P<0.05). Conclusions The coagulation function, immune function and oxidative stress indicators in AS patients are closely related with the disease activity and spinal mobility.
Key words
ankylosing spondylitis /
coagulation function /
immunity /
spinal mobility /
correlation
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