Correlation between the ratio of serum uric acid to high-density lipoprotein cholesterol and hypertension in overweight/obese individuals

ZOU Chacha; LI Jixin; WU Zijing; QIU Linjie; REN Yan; LI Meijie; LI Wenjie; ZHANG Jin

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Medical Journal of the Chinese People Armed Police Forces ›› 2026, Vol. 37 ›› Issue (1) : 19-25.

Correlation between the ratio of serum uric acid to high-density lipoprotein cholesterol and hypertension in overweight/obese individuals

ZOU Chacha¹, LI Jixin², WU Zijing^1,2, QIU Linjie², REN Yan², LI Meijie^1,2, LI Wenjie³, ZHANG Jin²

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Abstract

Objective To investigate the correlation between the ratio of serum uric acid to high-density lipoprotein cholesterol (UHR) and hypertension in overweight/obese individuals, as well as its discriminatory capability of UHR. Methods A total of 1624 overweight/obese adults who participated in health check-ups at Xiyuan Hospital of China Academy of Chinese Medical Sciences from January 1, 2021 to September 30, 2024 were included.. Participants were grouped based on hypertension status, and baseline levels were compared. R 4.2.0 and Empower RCH 4.1 were used to analyze the correlation between UHR and hypertension prevalence in overweight/obese individuals. Additionally, subgroup analyses were conducted based on gender, age, smoking status, alcohol consumption, presence of type 2 diabetes, other cardiovascular/cerebrovascular diseases, and family history of hypertension to assess the robustness of the research results. Receiver operating characteristic (ROC) curves were used to evaluate and compare the discriminatory efficacy of UHR for hypertension in overweight/obese individuals. Results A total of 1624 overweight/obese physical examination cases were included. After adjusting for 10 potential confounding factors, including gender, age, smoking history, drinking history, family history, and BMI via logistic regression, the following results were observed. The odds of hypertension increased by 1.0143 times (OR=1.0143) for each unit increase in UHR. After scaling UHR by a factor of 0.01, a one-unit increase in the scaled measure was associated with an odds ratio of 4.14 for hypertension. The high UHR group had 45.17 times higher odds of hypertension compared to the low UHR group (OR=45.17). Subgroup analysis revealed that the positive association between UHR and hypertension was stronger in females, middle-aged and older adults, and those with cardiovascular and cerebrovascular diseases. ROC curve analysis showed that the area under the curve (AUC) for UHR in discriminating hypertension in the overweight/obese population was 0.814 (95% CI: 0.7901-0.8375), with an optimal cutoff value of 324.813. Conclusions In overweight/obese individuals, UHR is significantly and non-linearly correlated with hypertension, and it has good discriminatory efficacy for hypertension in this population.

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hypertension / ratio of serum uric acid to high-density lipoprotein cholesterol / overweight/obese / correlation study

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ZOU Chacha, LI Jixin, WU Zijing, QIU Linjie, REN Yan, LI Meijie, LI Wenjie, ZHANG Jin. Correlation between the ratio of serum uric acid to high-density lipoprotein cholesterol and hypertension in overweight/obese individuals[J]. Medical Journal of the Chinese People Armed Police Forces. 2026, 37(1): 19-25

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