Clinical efficacy of sodium hyaluronate eye drops combined with hot compress patches in the treatment of dry eye syndromes

ZHOU Xibin; WANG Jing; WANG Lihua; GUO Guixian; WANG Wenjing

PDF(934 KB)

Medical Journal of the Chinese People Armed Police Forces ›› 2026, Vol. 37 ›› Issue (2) : 156-160.

Clinical efficacy of sodium hyaluronate eye drops combined with hot compress patches in the treatment of dry eye syndromes

ZHOU Xibin¹, WANG Jing², WANG Lihua¹, GUO Guixian¹, WANG Wenjing¹

Author information +

History +

Abstract

Objective To evaluate the clinical efficacy and safety of sodium hyaluronate eye drops combined with hot compress patches in the treatment of dry eye syndromes. Methods A multicenter prospective real-world clinical study was conducted, involving 303 patients with dry eye syndrome. The efficacy were evaluated at 1 week and 4 weeks of treatment through dry eye questionnaire, visual fatigue score, Schirmer I test, corneal fluorescein staining, and tear film break-up time. Results After 4 weeks of treatment, the total effective rate reached 94.0%. The dry eye questionnaire scores and visual fatigue scores at 1 week and 4 weeks of treatment were lower than those before treatment, and the scores at 4 weeks of treatment were lower than those at 1 week of treatment (P<0.01). The Schirmer I test values of both eyes at 1 week and 4 weeks of treatment were higher than those before treatment, and those at 4 weeks of treatment were higher than those at 1 week of treatment (P<0.01). The corneal fluorescein color scores at 1 week and 4 weeks of treatment were lower than those before treatment, and the scores at 4 weeks of treatment were lower than those at 1 week of treatment (P<0.01). The tear film break-up time at 1 week and 4 weeks of treatment was longer than that before treatment, and the time at 4 weeks of treatment was longer than at 1 week of treatment (P<0.01). The incidence of adverse events was 0.03%, with no serious adverse events or drug-related reactions. Conclusions Sodium hyaluronate eye drops combined with hot compress patches can effectively improve dry eye symptoms, reduce corneal damage and prolong the stability of the tear film. A 4-week treatment course is safe and effective, but the long-term efficacy needs further verification.

Key words

dry eye syndrome / sodium hyaluronate / hot compress / combined therapy / eye drops and patches used together

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

ZHOU Xibin, WANG Jing, WANG Lihua, GUO Guixian, WANG Wenjing. Clinical efficacy of sodium hyaluronate eye drops combined with hot compress patches in the treatment of dry eye syndromes[J]. Medical Journal of the Chinese People Armed Police Forces. 2026, 37(2): 156-160

References

[1] 亚洲干眼协会中国分会,海峡两岸医药卫生交流协会眼科学专业委员会眼表与泪液病学组,中国医师协会眼科医师分会眼表与干眼学组.中国干眼专家共识:定义和分类(2020年)[J].中华眼科杂志,2020,56(6):418 -422.
[2] Messmer E M.The pathophysiology,diagnosis,and treatment of dry eye disease[J].Dtsch Arztebl Int,2015,112 (5):71-81.
[3] Li M, Gong L, Chapin W J,et al.Assessment of vision-related quality of life in dry eye patients[J].Invest Ophthalmol Vis Sci,2012,53(9):5722-5727.
[4] Deschamps N, Ricaud X,Rabut G,et al.The impact of dry eye disease on visual performance while driving[J].Am J Ophthalmol,2013,156(1):184-189.
[5] Yu J, Asche C V, Fairchild C J.The economic burden of dry eye disease in the United States:a decision tree analysis[J].Cornea,2011,30(4):379-387.
[6] Liu Z, Pflugfelder S C.Corneal surface regularity and the effect of artificial tears in aqueous teardeficiency[J].Ophthalmology,1999,106(5):939-943.
[7] 亚洲干眼协会中国分会,海峡两岸医药卫生交流协会眼科学专业委员会眼表与泪液病学组,中国医师协会眼科医师分会眼表与干眼学组.中国干眼专家共识:检查和诊断(2020年)[J].中华眼科杂志,2020,56(10):741-747.
[8] Tsubota K,Yokoi N,Shimazaki J,et al.New perspectives on dry eye definition and diagnosis:a consensus report by the Asia Dry Eye Society[J].Ocul Surf,2017,15(1):65-76.
[9] Tsubota K, Yokoi N, Watanabe H, et al.A new perspective on dry eye classification:proposal by the Asia Dry Eye Society[J].Eye Contact Lens,2020,46(Suppl 1):S2-S13.
[10] 刘祖国,王华.关注干眼慢性疾病管理体系的建设[J].中华眼科杂志, 2018, 54(2):81-83.
[11] 黄蒂,吴真真,李晓娟,等.玻璃酸钠联合重组人表皮生长因子治疗干眼的效果及对FBUT、泪液分泌量和OSDI评分的影响[J].中外医学研究,2022,20(23):17-20.
[12] 韩雪, 姚靖,王艳玲,等.中药熏蒸联合人工泪液治疗干眼症的临床效果[J].中国民康医学,2020,32(4):115-117.
[13] 孟超.中药熏眼联合玻璃酸钠滴眼液治疗干眼症临床观察[J].实用中医药杂志, 2019, 35 (8):1022-1023
[14] 王爽,张威.干眼症临床研究进展[J].临床医学进展,2023,13(12):19787-19792.
[15] 熊涛,张宸,邵佳,等.干眼症治疗的研究进展[J].新疆医科大学学报,2025,48(6):858-863.
[16] 方琦琦,吴婷婷,邢健强.重组牛碱性成纤维细胞生长因子滴眼液治疗白内障术后干眼症的效果[J].西北药学杂志,2024,39(3):149-152.
[17] 凌沛学,贺艳丽,白若琬,等.玻璃酸钠结构及理化性质的研究进展[J].中国生化药物杂志,2000,21(3):152-154.
[18] 刘鹏里,林云燕,林婵.雷火灸联合玻璃酸钠滴眼液治疗干眼症的效果及对炎症因子的影响[J].中国当代医药,2025,32(13):79-83.
[19] 赵志玲,王雅丽.睑板腺按摩联合玻璃酸钠滴眼液治疗干眼患者的效果[J].中国民康医学,2021,33(3):154-156.
[20] 李贵明,苏杭,毛祖红.0.05%环孢素滴眼液联合玻璃酸钠滴眼液治疗白内障术后干眼症的临床效果[J]. 临床合理用药,2024,17(1):139-141,145.
[21] 陈星怡,罗燕,梁明,等.国产玻璃酸钠联合聚乙二醇滴眼液治疗斜视术后干眼症的效果观察[J].河北医学,2023,29(3):511-516.
[22] 周进,李丽,石玉萍,等. 地夸磷索钠联合玻璃酸钠治疗FS-LASIK术后干眼的临床效果研究[J]. 中国现代药物应用,2022,16(15):137-140.
[23] 王大虎,徐蔚,刘新泉. 眼部热敷贴治疗睑板腺功能障碍性干眼的临床效果及安全性评估[J]. 中国眼镜科技杂志, 2022,(4): 114-123.
[24] 姚月蓉,张殷建. 热敷疗法的改良及其在眼科疾患中的应用 [J]. 中国中医眼科杂志, 2019, 29 (1): 79-81.
[25] 童国勇,林锦,孟倩,等. 蒸汽眼罩技术研究及应用概况 [J]. 中国中医眼科杂志, 2020, 30 (11): 818-820.
[26] 农璐琪. 蒸汽眼罩改善干眼的临床观察及基于网络药理学探讨干眼熏蒸方机制[D]. 北京:北京中医药大学, 2021.
[27] 李能,来坚.氟米龙联合玻璃酸钠滴眼液治疗干眼的效果及对泪液中炎症因子的影响[J].国际眼科杂志, 2021, 21(3): 509-514.