Objective To analyze the efficacy of plum blossom needle combined with minoxidil tincture in the treatment of androgenetic alopecia. Methods The research subjects were 120 patients with androgenetic alopecia who visited the dermatology outpatient department of Henan Provincial Corps Hospital of Chinese People's Armed Police Force from January 2023 to December 2024, and they were randomly divided into a control group (n=60, treated with minoxidil tincture) and an experimental group (n=60, treated with plum blossom needle combined with minoxidil tincture). The hair growth status, hair loss symptom scores and clinical treatment effective rates of the two groups before treatment and after the completion of the treatment cycle of 12 weeks were compared. Results After completing the cycle treatment, the hair growth rate of the experimental group was faster than that of the control group (110.22±26.89)μm/d vs. (36.98±7.97)μm/d, and the hair growth length was also longer than that of the control group (20.92±8.06)mm vs. (6.72±1.53)mm, with statistically significant differences (P＜0.05). After the completion of the cycle treatment, the reduction rate of the scores of greasiness, pruritus and hair loss symptoms in the experimental group was significantly higher than that in the control group (P＜0.05). Compared with the control group (78.33%), the total effective rate of treatment in the experimental group (96.67%) was significantly higher, with statistically significant differences (P＜0.05). Conclusions Plum blossom needle combined with minoxidil tincture in the treatment of androgenetic alopecia is definite, and can effectively alleviate the symptoms of hair loss and promote hair growth, which has a high clinical application value.