[1] Chen Y, Gan W, Cheng Z, et al. Plant molecules reinforce bone repair: novel insights into phenol-modified bone tissue engineering scaffolds for the treatment of bone defects[J]. Mater Today Bio, 2024, 24: 100920.
[2] Ashton A, Foster R G, Jagannath A. Photic entrainment of the circadian system[J]. Int J Mol Sci, 2022, 23(2): 729-741.
[3] Dong P, Gu X, Zhu G, et al. Melatonin induces osteoblastic differentiation of mesenchymal stem cells and promotes fracture healing in a rat model of femoral fracture via neuropeptide Y/neuropeptide Y receptor Y1 signaling[J]. Pharmacology, 2018, 102(5-6): 272-280.
[4] Li Y, Guan H, Tian R, et al. Melatonin promotes the restoration of bone defects via enhancement of miR-335-5p combined with inhibition of TNFα/NF-κB signaling[J]. FASEB J, 2023, 37(1): e22711.
[5] Song W, Ma Z, Wang C, et al. Pro-chondrogenic and immunomodulatory melatonin-loaded electrospun membranes for tendon-to-bone healing[J]. J Mater Chem B, 2019, 7(42): 6564-6575.
[6] Chan Y H, Ho K N, Lee Y C, et al. Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects[J]. Stem Cell Res Ther, 2022, 13(1): 73-91.
[7] Park K H, Kang J W, Lee E M, et al. Melatonin promotes osteoblastic differentiation through the BMP/ERK/Wnt signaling pathways[J]. J Pineal Res, 2011, 51(2): 187-194.
[8] Zhu G, Ma B, Dong P, et al. Melatonin promotes osteoblastic differentiation and regulates PDGF/AKT signaling pathway[J]. Cell Biol Int, 2020, 44(2): 402-411.
[9] Murodumi H, Shigeishi H, Kato H, et al. Melatonin-induced miR-181c-5p enhances osteogenic differentiation and mineralization of human jawbone-derived osteoblastic cells[J]. Mol Med Rep, 2020, 22(4): 3549-3558.
[10] 王志锋, 赵 威, 朱建华, 等. 聚己内酯-褪黑素支架治疗骨缺损修复效果分析[J].临床军医杂志, 2023, 51(1): 19-22.
[11] Köse D, Köse A, Halıcı Z, et al. Do peripheral melatonin agonists improve bone fracture healing? The effects of agomelatine and ramelteon on experimental bone fracture[J]. Eur J Pharmacol, 2020, 887: 173577.
[12] Cao Z, Geng X, Jiang X, et al. Melatonin attenuates AlCl3-induced apoptosis and osteoblastic differentiation suppression by inhibiting oxidative stress in MC3T3-E1 Cells[J]. Biol Trace Elem Res, 2020, 196(1): 214-222.
[13] Zhou R, Ma Y, Tao Z, et al. Melatonin inhibits glucose-induced apoptosis in osteoblastic cell line through PERK-eIF2α-ATF4 pathway[J]. Front Pharmacol, 2020, 11: 602307.
[14] 吕文正.褪黑素调控Akt/Nrf 2/HO-1通路减轻糖皮质激素诱导成骨细胞凋亡[D]. 沈阳: 中国医科大学, 2023.
[15] Zhou L, Chen X, Yan J, et al. Melatonin at pharmacological concentrations suppresses osteoclastogenesis via the attenuation of intracellular ROS[J]. Osteoporos Int, 2017, 28(12): 3325-3337.
[16] Zhu X, Zhang Y, Yang H, et al. Melatonin suppresses Ti-particle-induced inflammatory osteolysis via activation of the Nrf2/Catalase signaling pathway[J]. Int Immunopharmacol, 2020, 88: 106847.
[17] Maria S, Samsonraj R M, Munmun F, et al. Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis[J]. J Pineal Res, 2018, 64(3): 10-32.
[18] Choi J H, Jang A R, Park M J, et al. Melatonin inhibits osteoclastogenesis and bone loss in ovariectomized mice by regulating PRMT1-mediated signaling[J]. Endocrinology, 2021, 162(6): bqab057.
[19] Histing T, Anton C, Scheuer C, et al. Melatonin impairs fracture healing by suppressing RANKL-mediated bone remodeling[J]. J Surg Res, 2012, 173(1): 83-90.
[20] Liu P I, Chang A C, Lai J L, et al. Melatonin interrupts osteoclast functioning and suppresses tumor-secreted RANKL expression: implications for bone metastases[J]. Oncogene, 2021, 40(8): 1503-1515.
[21] Wang X, Jiang W, Pan K, et al. Melatonin induces RAW264.7 cell apoptosis via the BMAL1/ROS/MAPK-p38 pathway to improve postmenopausal osteoporosis[J]. Bone Joint Res, 2023, 12(11): 677-690.
[22] Zheng S, Zhou C, Yang H, et al. Melatonin accelerates osteoporotic bone defect repair by promoting osteogenesis-angiogenesis coupling[J]. Front Endocrinol (Lausanne), 2022, 13: 826660.
[23] Deng L, Hou M, Lv N, et al. Melatonin-encapsuled silk fibroin electrospun nanofibers promote vascularized bone regeneration through regulation of osteogenesis-angiogenesis coupling[J]. Mater Today Bio, 2024, 25: 100985.
[24] Lv N, Hou M, Deng L, et al. A sponge-like nanofiber melatonin-loaded scaffold accelerates vascularized bone regeneration via improving mitochondrial energy metabolism[J]. Mater Today Bio, 2024, 26: 101078.
[25] Chen T, Wu Z, Hou Q, et al. The dual angiogenesis effects via Nrf2/HO-1 signaling pathway of melatonin nanocomposite scaffold on promoting diabetic bone defect repair[J]. Int J Nanomedicine, 2024, 19: 2709-2732.
[26] Qiu X, Wang X, Qiu J, et al. Melatonin rescued reactive oxygen species-impaired osteogenesis of human bone marrow mesenchymal stem cells in the presence of tumor necrosis factor-alpha[J]. Stem Cells Int, 2019, 2019: 6403967.
[27] Ren M, Liu H, Jiang W, et al. Melatonin repairs osteoporotic bone defects in iron-overloaded rats through PI3K/AKT/GSK-3β/P70S6k signaling pathway[J]. Oxid Med Cell Longev, 2023, 7718155.
[28] Wang X, Liang T, Zhu Y, et al. Melatonin prevents bone destruction in mice with retinoic acid-induced osteoporosis[J]. Mol Med, 2019, 25(1): 43-57.
[29] Gu C, Zhou Q, Hu X, et al. Melatonin rescues the mitochondrial function of bone marrow-derived mesenchymal stem cells and improves the repair of osteoporotic bone defect in ovariectomized rats[J]. J Pineal Res, 2024, 76(1): e12924.
[30] Chen W, Chen X, Chen A C, et al. Melatonin restores the osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells by preserving SIRT1-mediated intracellular antioxidant properties[J]. Free Radic Biol Med, 2020, 146: 92-106.
[31] Liu H D, Ren M X, Li Y, et al. Melatonin alleviates hydrogen peroxide induced oxidative damage in MC3T3-E1 cells and promotes osteogenesis by activating SIRT1[J]. Free Radic Res, 2022, 56(1): 63-76.
[32] Fan C, Feng J, Tang C, et al. Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage[J]. Stem Cell Res Ther, 2020, 11(1): 442-464.
[33] Xiao L, Lin J, Chen R, et al. Sustained release of melatonin from GelMA liposomes reduced osteoblast apoptosis and improved implant osseointegration in osteoporosis[J]. Oxid Med Cell Longev, 2020, 6797154.
[34] Zhao M, Qiu D, Miao X, et al. Melatonin delays arthritis inflammation and reduces cartilage matrix degradation through the sirt1-mediated NF-κB/Nrf2/TGF-β/BMPs pathway[J]. Int J Mol Sci, 2024, 25(11): 6202-6226.
[35] Kırmızı D, Sehirli A Ö, Sayiner S, et al. Effects of melatonin against experimentally induced apical periodontitis in rats[J]. Aust Endod J, 2024, 50(2): 218-226.
[36] Santos R, Machado N, Cantiga-Silva C, et al. Modulatory influence of melatonin on apical periodontitis in Wistar rats fed a high-fat diet[J]. Arch Oral Biol, 2023, 153: 105749.
[37] Xin X, Liu J, Liu X, et al. Melatonin-derived carbon dots with free radical scavenging property for effective periodontitis treatment via the Nrf2/HO-1 pathway[J]. ACS Nano, 2024, 18(11): 8307-8324.