Objective To explore the correlation between serum total bilirubin and coronary atherosclerotic lesions in patients with Type 2 diabetes (T2DM) complicated with metabolic dysfunction. Methods A retrospective study was conducted on the clinical data of patients with T2DM and metabolic dysfunction who were hospitalized in the First Hospital of Qinhuangdao from February 2016 to October 2023. According to coronary artery computed tomography angiography (CTA) results, the patients were grouped, and the gender, age, serum total bilirubin, and lipid indicators of the two groups were collected for comparison. The correlations between serum total bilirubin levels and plaque burden, involved segments, and plaque phenotypes was also explored. Results A total of 77 patients were included in this study. According to the CTA results, they were divided into a T2DM with the coronary heart disease (CHD) group (n=42) and a T2DM group (n=35).The serum total bilirubin level in the T2DM with CHD group was significantly lower than that in the T2DM group [9.40(7.25-12.53) vs. 10.50(6.65-13.95)μmol/L], and the difference was statistically significant (P<0.05). Compared with T2DM group, the serum total bilirubin levels in the T2DM+CHD group were significantly negatively correlated with plaque number and the number of involved segments (r=-0.82、-0.58,P<0.001), and also negatively correlated with calcification, non-calcification, and mixed plaques (r=-0.49, -0.57, -0.92, P<0.05). Conclusions Serum total bilirubin levels are significantly reduced in T2DM patients with CHD and are associated with higher coronary plaque burden and unstable plaque characteristics.
Key words
type 2 diabetes /
serum total bilirubin /
coronary atherosclerosis /
plaque /
metabolic dysfunction
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