目的 观察钆贝葡胺注射液（gadobenate dimeglumine injection ,Gd-BOPTA）作为磁共振的特异性对比剂，在1 h延时肝胆期肝脏病灶的信号强度，分析良恶性病灶的信号特征及与病理的关系。
Abstract
Objective To observe the images with injection of Gd-BOPTA (gadobenate dimeglumine, Gd-BOPTA injection, multihance) as the dual phase MRI contrast agent and after the acquisition of one-hour delayed hepatobiliary-phase images and to analyze signal attenuation and characteristics in both benign and malignant liver lesions after intravenous bolus administration of Gd-BOPTA.Methods Fifty patients were suspected of having liver lesions. The seventy liver lesions of theirs underwent MRI scan and were confirmed by biopsy pathological diagnosis or operation in two weeks. The lesion to liver contrast/noise ratio(CNR) and signal/noise ratio (SNR)were calculated both in benign and malignant liver lesions.Results After one-hour delay, 97.8% of the malignant lesions and 40% of the benign lesions showed low signal. There was statistically significant difference between the two groups (P＜0.05). SNR and CNR illustrated some difference in benign and malignant lesions. Conclusions Although the hypointense signal in the hepatobiliary-phase of the Gd-BOPTA enhanced magnetic resonance imaging was typically a histological feature of malignant lesions in liver lesions, some of the benign lesions also showed a similar signal due to the internal structure. Differential diagnosis betweem benign liver lesions and malignant ones remains difficult.
关键词
磁共振对比剂 /
磁共振成像 /
钆贝葡胺 /
肝脏局灶性病变
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参考文献
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