目的 探讨14~17+6孕周超声筛查胎儿畸形的临床价值。方法 回顾性分析2012-2014年在我院进行超声检查的14~17+6孕周胎儿1200例,对其进行标准切面检查,包括测量胎儿双顶径、腹围、股骨长、羊水及胎儿心率,观察头颅、心脏、腹部及脊柱、四肢。结果 受检的1200例胎儿中,37例胎儿发现结构异常。其中胎儿水肿6例(包括颈部水囊瘤4例),脉络丛囊肿10例,露脑畸形3例,全前脑3例,脐膨出2例,心脏异常5例,肢体异常2例,脊柱异常2例,巨膀胱3例,连体双胎1例。结论 14~17+6孕周的超声检查可以有效地检出胎儿畸形,是产前超声筛查胎儿畸形的重要阶段。
Abstract
Objective To evaluate the value of ultrasonography in screening fetal anomaly at 14 to 17+6 weeks. Methods A total of 1200 women at 14 to 17+6 weeks of gestation were analyzed retrospectively. We measured the biparietal diameter, abdominal circumference, femur length, amniotic fluid and fetal heart rate, and observed the head, heart, abdomen, spine and limbs. Results It was found that 37 fetuses had structural malformations, including 6 cases of hydrops, 10 cases of choroid plexus cysts, 3 cases of exencephaly, 3 cases of holoprosencephaly, 2 cases of omphalocele, 5 cases of congenital heart disease, 2 cases of limb deformity, 2 cases of spine deformity, 3 cases of megabladder, 1 case of conjoined twins. Conclusions It is effective to screen fetal anomaly at 14 to 17+6 weeks by ultrasonography and it is important for early fetal diagnosis.
关键词
超声 /
胎儿畸形 /
孕14~17+6周
Key words
ultrasonography /
fetal anomaly /
14-17+6 th week of gestation
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参考文献
[1] 陈争春,黄春玲.11~13+6孕周与14~17+6孕周胎儿筛查的作用[J].中国优生与遗传杂志,2011,19(10):81-121.
[2] Caughey A,Kuppernann M,Norton M,et al.Nuchal translucency and first trimester biochemical markers for down syndrome screening: a cost-effectiveness analysis[J].Am J Obstet Gynecol,2002,187(5):1239-1245.
[3] 徐 慧,燕 风,郭芬芬,等.胎儿颈项透明层厚度与染色体异常关系的探讨[J].中国产前诊断杂志(电子版),2012,4(3):19-22.
[4] Snijders R I M,Noble P,Sebire N,et al.UKmulticentre project on assessment of risk trisomy 21 by maternal age and fetal nuchal translucency thickness at 10-14 weeks of gestation[J].Lancet, 1998,351(9125):343-346.
[5] 许 健.胎儿脉络丛囊肿的临床意义分析[J].中国优生与遗传杂志,2010,18(1):95-96.
[6] 耿丹明,王 鸿,吴琳琅,等.彩色多普勒超声检测12~14孕周胎儿三尖瓣返流的应用价值[J].临床超声医学杂志,2013,15(11):790-792.
[7] Syngelaki A,Chelemen T,Dagklis T,et al.Challenges in the diagnosis of fetal non-chromosomal abnormalities at 11-13 weeks[J].Prenat Diagn,2011,31(1):90-102.
[8] 耿秋莹,孔凡斌,严英榴,等.孕早期经腹部超声筛查胎儿先天性心脏病[J].中国医学影像技术,2013,29(8):1344-1347.
[9] 孔凡斌,宁 燕,严英榴,等.孕早期超声筛查胎儿心外畸形的价值初探[J].临床超声医学杂志,2013,15(10):665-667.
[10] Unsal A,Sezer S D,Meteoale L,et al.Ultrasonographic prenatal diagnosis of isolated acephaly[J].Diagn Interv Radiol, 2007,13(4):196-198.
[11] Haak M C,Twisk I W R,Van Vugt J M G.How successful is fetal echocardiographic examination in the first trimester of pregnancy [J].Ultrasound Obstet Gynecol,2002,20(1):9-13.
[12] Allan L D.Cardiac anatomy screening :what is the best time for screening in pregnancy?[J].Curr Opin Obstet Gynecol,2003,15(2):143-146.
[13] 胡雁来,赵 巍,严英榴.中孕早期普通超声检查易发现的胎儿异常种类[J].复旦学报(医学版),2013,40(5):598-600.
[14] 玄英华,王 莉,马玉庆.早孕期胎儿规范化超声检查的意义[J].中华医学超声杂志(电子版), 2013.10(11):59-63.
[15] Ilescu D,Tudorache S,Comanescu A,et al.Improved detection rate of structural abnormalities in the first trimester using an extended examination protocol[J].Ultrasound Obstet Gynecol,2013,42(3):300-309.