目的 探讨妊娠期高血压(简称妊高征;pregnancy-induced hypertension,PIH)患者产后颈动脉血管结构及功能的变化。方法 选取2014-04至2016-04就诊于武警江西总队医院妇产科的108例孕妇为研究对象,分为研究组(PIH患者,56例)和对照组(正常妊娠孕妇,52例),分别于妊娠晚期及产后3、6个月应用超声射频信号血管分析技术测量颈动脉内中膜厚度(IMT)和颈动脉血管弹性,评价指标包括脉搏波传导速度(PWVβ)、僵硬度(β)、顺应性(AC)、膨大指数(AI)、弹性系数(EP)。结果 研究组孕妇妊娠晚期颈动脉内中膜厚度明显高于对照组[(617.83±187.62) vs (454.36±142.54)],且血管弹性指标PWVβ、β、AI及Ep较对照组升高[(6.63±1.39、11.24±1.77、13.57±4.58、134.52±19.62) vs (5.54±1.21、5.54±0.88、-1.67±6.92、71.02±15.18)],而AC较对照组明显减低[(0.63±0.18) vs (1.02±0.24)],两组差异比较均有统计学意义(P＜0.05),至产后3、6个月两组孕妇颈动脉内中膜厚度及五项颈动脉血管弹性指标(PWVβ、β、AI、Ep及AC)相比差异均无统计学意义(P＞0.05)。结论 妊娠晚期PIH患者颈动脉血管结构和弹性会发生改变,至产后3个月颈动脉血管结构和弹性可恢复正常,超声射频信号血管分析技术对评估血管结构和弹性功能具有很高的应用价值。
Abstract
Objective To investigate the changes of postoperative carotid artery structure and function in patients with hypertensive disorder complicating pregnancy (pregnancy-induced hypertension, PIH).Methods 108 pregnant women who were admitted to our hospital between April 2014 and April 2016 were selected as subjects and divided into the study group (56 patients with PIH) and the control group (52 cases of normal pregnant women). IMT and carotid artery elasticity were measured at the end of gestation and at 3 and 6 months postpartum. The indexes included pulse wave velocity (PWVβ),stiffness (β), compliance (AC), swelling index (AI) and elasticity coefficient (EP)].Results Carotid arteries in the study group were significantly thicker than those in the control group [(617.83±187.62) μm vs (454.36±142.54) μm], and such vascular elasticity indexes as PWVβ, β, AI and Ep were higher than those in the control group (0.63±0.18, -1.67±6.92, 71.02±15.18), while AC was significantly lower than that of the control group (0.63±0.18, 13.57±4.58,134.52±19.62) vs (5.54±1.21,5.54±0.88,-1.67±6.92,71.02±15.18) vs (1.02±0.24)]. The difference between the two groups was statistically significant (P＜0.05)., At 3 and 6 months postpartum, the difference in the carotid intima-media thickness and five indexes of carotid artery elasticity (PWVβ, Β, AI, Ep and AC) was not statistically significant (P>0.05)between the two groups.Conclusions The structure and elasticity of carotid arteries in PIH patients in late pregnancy can be changed and restored to normal at 3 months postpartum. Ultrasound RF signal angiography is of high value in assessing vascular structure and elasticity.
关键词
妊娠期高血压疾病 /
颈动脉 /
血管弹性 /
超声射频信号血管分析技术
Key words
pregnancy-induced hypertension /
carotid artery /
vascular elasticity /
ultrasound RF signal vascular analysis technique
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