目的 通过观察治疗前后患者血清中白介素-18、可溶性细胞间黏附分子-1、胰岛素样生长因子-1的变化,探讨马来酸桂哌齐特(克林澳)联合丹参川芎嗪注射液治疗脑梗死患者的疗效。方法 选择2015-09至2018-12在医院诊治的脑梗死患者135例,根据治疗方法不同分为对照组(n=65)与联合组(n=70)。对照组给予克林澳治疗,联合组在对照组治疗的基础上联合丹参川芎嗪注射液治疗,两组均治疗观察3个月,记录与检测患者血清IL-18、sICAM-1、IGF-1的变化。结果 所有患者均顺利完成治疗,治疗期间无严重不良反应发生。联合组的总有效率97.1%,高于对照组的86.2%(P＜0.05)。两组治疗后的MoCA评分、颅脑椎动脉与基底动脉血流速度都高于治疗前,联合组评分为(27.38±1.49)分,高于对照组的(22.88±2.69)分。两组治疗后的血清IL-18、sICAM-1、IGF-1水平均低于治疗前,联合组也低于对照组(P＜0.05)。结论 克林澳联合丹参川芎嗪注射液治疗脑梗死能抑制血清IL-18、sICAM-1、IGF-1的表达,改善脑血流状况,提高患者的认知功能与总体治疗效果。
Abstract
ObjectiveTo investigate the therapeutic effect of Cinepazide Maleate combined with Danshen Ligustrazine injection against cerebral infarction by observing changes in serum interleukin (IL)-18, soluble intercellular adhesion molecule (sICAM)-1, and insulin-like growth(IGF)-1 in patients.Methods One hundred and thirty-five cases of patients with cerebral infarction who were treated in our hospital between September 2015 and December 2018 were selected and divided into the control group(n=65) and the combination group(n=70) according to treatment methods. The control group was treated with Cinepazide Maleate, while the combination group was additionally treated with Danshen Ligustrazine injection. Both groups were treated for 3 months, and the levels of serum IL-18, sICAM-1 and IGF-1 were detected and recorded.Results All the patients completed the treatment and no serious adverse reactions occurred during the treatment. The total effective rate of the combination group was 97.1%, which was significantly higher than that of the control group (86.2%) (P<0.05). The MoCA scores, cranial vertebral artery and basilar artery blood flow velocity in the two groups were significantly higher after treatment (P<0.05), especially in the combination group (P<0.05). The levels of serum IL-18, sICAM-1 and IGF-1 in the two groups were significantly lower after treatment (P<0.05), particularly in the combination group (P<0.05).Conclusions Cinepazide Maleate combined with Danshen Ligustrazine injection, when used in the treatment of cerebral infarction, can inhibit the expressions of serum IL-18, sICAM-1 and IGF-1, boost the cerebral blood flow and improve the cognitive function and overall therapeutic effect.
关键词
克林澳 /
丹参川芎嗪注射液 /
脑梗死 /
白介素-18 /
可溶性细胞间粘附分子-1
Key words
Cinepazide Maleate /
Danshen Ligustrazine injection /
cerebralinfarction /
interleukin-18 /
soluble intercellular adhesion molecule-1
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参考文献
[1] Guo Y E, Togher L, Power E, et al. Validation of the stroke and aphasia quality of life scale in a multicultural population[J]. Disabil Rehabil, 2016, 38(26): 2584-2592.
[2] Lin H F, Chern C M, Chen H M, et al. Validation of NINDS-VCI neuropsychology protocols for vascular cognitive impairment in Taiwan[J]. PLoS One, 2016, 11(6): e0156404.
[3] Mou Z, Chen Z, Yang J, et al. Acoustic properties of vowel production in Mandarin-speaking patients with post-stroke dysarthria[J]. Sci Rep, 2018, 8(1):14188.
[4] 王义彦,贺朝勇,邓 翠.丹参川芎嗪联合阿托伐他汀治疗不稳定心绞痛效果及对血清促炎性细胞因子和血管内皮细胞功能的影响[J].解放军医药杂志,2018,30(5):86-89.
[5] 曾 源,林雪妹,邓可波,等.痰热清注射液联合丹参川芎嗪注射液治疗慢性阻塞性肺疾病急性加重期临床研究[J].国际中医中药杂志,2018,40(4):296-299.
[6] Castro A M, Carmona F D, Rodrigues A M, et al. Incidence and predictors of cardiovascular events in a cohort of patients with rheumatoid arthritis[J]. Acta Reumatol Port, 2016, 41(3): 213-219.
[7] Jimenez M C, Rexrode K M, Kotler G, et al. Association between markers of inflammation and total stroke by hypertensive status among women[J]. Am J Hypertens, 2016, 29(9): 1117-24.
[8] Pearson M J, Mungovan S F, Smart N A. Effect of aerobic and resistance training on inflammatory markers in heart failure patients: systematic review and meta-analysis[J]. Heart Fail Rev, 2018, 23(2): 209-223.
[9] Ren H Y, Khera A, De Lemos J A, et al. Soluble endothelial cell-selective adhesion molecule and incident cardiovascular events in a multiethnic population[J]. Am Heart J, 2017, 191(8): 55-61.
[10] 潘 轲,张 涛.丹参川芎嗪注射液联合针灸治疗外伤性蛛网膜下腔出血的临床研究[J].中西医结合心脑血管病杂志,2018,16(7):943-946.
[11] 王倩雅,何仲贤,王婵妮,等.丹参川芎嗪注射液治疗妊娠期高血压疗效及对LIF、Apelin表达的影响[J].云南中医学院学报,2018,41(2):55-57,60.
[12] 陈国宁,林泽辉,杜永明,等.丹参川芎嗪注射液对缺血性脑卒中患者同型半胱氨酸、高敏C反应蛋白和血脂水平的影响及疗效观察[J].中国医药导报,2018,15(1):76-79.
[13] 俞 勇,陈 明,彭爱明,等.丹参川芎嗪注射液联合高压氧对急性脊髓损伤早期并发症的预防作用[J].中国药房,2018,29(2):244-247.
[14] Staszewski J, Piusinska M R, Brodacki B, et al. IL-6, PF-4, sCD40 L, and homocysteine are associated with the radiological progression of cerebral small-vessel disease: a 2-year follow-up study[J]. Clin Interv Aging, 2018, 13(9): 1135-1141.
[15] 王 军,张文胜,裴效瑞,等.丹参川芎嗪注射液联合利伐沙班治疗下肢深静脉血栓的临床研究[J].现代药物与临床,2018,33(12):3335-3339.
[16] Ryan A S, Li G, Hafer M C, et al. Resistive training and molecular regulators of vascular-metabolic risk in chronic stroke[J]. J Stroke Cerebrovasc Dis, 2017, 26(5): 962-968.
[17] Lu W J, Zeng L L, Wang Y, et al. Blood micro RNA-15a correlates with IL-6, IGF-1 and acute cerebral ischemia[J]. Curr Neurovasc Res, 2018, 15(1): 63-71.
[18] Okamoto A, Wajima D, Tei R, et al. A case of a pituitary adenoma diagnosed as carney complex syndrome in an older female patient[J]. No Shinkei Geka, 2017, 45(3): 225-231.
[19] Okoreeh A K, Bake S, Sohrabji F. Astrocyte-specific insulin-like growth factor-1 gene transfer in aging female rats improves stroke outcomes[J]. Glia, 2017, 65(7): 1043-1058.
[20] Zhang G, Guo X, Chen L, et al. Interferon-gamma promotes neuronal repair by transplanted neural stem cells in ischemic rats[J]. Stem Cells Dev, 2018, 27(5): 355-366.
[21] Towfighi A, Cheng E M, Ayala-Rivera M, et al. Randomized controlled trial of a coordinated care intervention to improve risk factor control after stroke or transient ischemic attack in the safety net: secondary stroke prevention by Uniting Community and Chronic care model teams Early to End Disparities (SUCCEED)[J]. BMC Neurol, 2017, 17(1): 24.
[22] 张 波,伍海军,钟志军,等.丹参川芎嗪注射液对脑出血大鼠神经功能、脑水肿及神经元凋亡的影响研究[J].实用心脑肺血管病杂志,2018,26(11):62-66.
[23] 林 颜,阮树斌,陈晓东,等.丹参川芎嗪注射液对重度烧伤患者炎性因子影响及预防脓毒症发生效果分析[J].河北医学,2018,24(3):382-385.
[24] Buerki S E, Grandgirard D, Datta A N, et al. Inflammatory markers in pediatric stroke: an attempt to better understanding the pathophysiology[J]. Eur J Paediatr Neurol, 2016, 20(2): 252-260.
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