[1] McMahon H A, Stranix J T, Lee Z H, et al. Management of gustilo type IIIC injuries in the lower extremity[J]. Clin Plast Surg, 2021, 48(2): 267-276. [2] Hoogervorst L A, Hart M J, Simpson P M, et al. Outcomes of severe lower limb injury with Mangled Extremity Severity Score≥ 7[J]. BJJ, 2021, 103(4): 769-774. [3] Arundel C, Mandefield L, Fairhurst C, et al. Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial[J]. Lancet, 2025, 405(10490): 1689-1699. [4] Ng H J H, Ang E J G, Premchand A X R, et al. Limb salvage versus primary amputation in Gustilo-Anderson IIIB and IIIC tibial fractures: a systematic review and meta-analysis[J]. Arch Orthop Trauma Surg, 2023, 143(8): 4961-4976. [5] Sethuraman A S, Devendra A, Rajasekaran R B, et al. Is lower limb salvage worthwhile after severe open tibial fractures in a developing country? An analysis of surgical outcomes, quality of life and cost implications[J]. Injury, 2021, 52(4): 996-1001. [6] Schade A T, Sabawo M, Nyamulani N, et al. Functional outcomes and quality of life at 1-year follow-up after an open tibia fracture in Malawi: a multicentre, prospective cohort study[J]. Lancet Glob Health, 2023, 11(10): e1609-e1618. [7] Stahel P F, Kaufman A M. Contemporary management of open extremity fractures: what you need to know[J]. J Trauma Acute Care Surg, 2024, 97(1): 11-22. [8] Zaver V, Kankanalu P. Negative pressure wound therapy[M]//StatPearls. Treasure Island (FL): Stat Pearls Publishing, 2023. [9] Dixon J E, Rankin I A, Rangarajan S, et al. Scottish Open Fractures of Tibia (SOFT) audit: a multi-centre retrospective review of ortho-plastic management of tibial shaft fractures at major trauma centres (MTCs) in Scotland[J]. Surgeon, 2025, 23(2): 87-93. [10] Ong S W, Gan L P, Chia D S Y. The double muscle gastrocnemius-soleus flap in resurfacing large lower limb defects: modifications and outcomes[J]. J Orthop, 2020, 17: 13-16. [11] Li S, Xu X. The role of the medial head of the gastrocnemius myocutaneous flap transfer in the management of prosthesis exposure and deep joint infection following total knee arthroplasty[J]. Arch Orthop Traum Surg, 2024, 145(1): 26.[12] Gkiatas I, Korompilia M, Kostas-Agnantis I, et al. Gastrocnemius pedicled muscle flap for knee and upper tibia soft tissue reconstruction. A useful tool for the orthopaedic surgeon[J]. Injury, 2021, 52(12): 3679-3684. [13] Cheng X, Yao Y, Liu K, et al. Free iliac crest grafting technology for the management of critical-sized tibial bone defect[J]. BMC Musculoskelet Disord, 2024, 25(1): 201. [14] Konda S R, Littlefield C P, Carlock K D, et al. Autogenous iliac crest bone grafting for tibial nonunions revisited: does approach matter?[J]. Arch Orthop Trauma Surg, 2022, 142(6): 961-968. [15] Kook I, You J, Kim D H, et al. A retrospective cohort study of autogenous iliac strut bone grafting in large bone defects of the lower extremity[J]. Sci Rep, 2024, 14(1): 6059. [16] Poutoglidou F, Khan R, Krkovic M. Amputation versus reconstruction in severe lower extremity injury: a systematic review and meta-analysis[J]. Arch Bone Jt Surg, 2023, 11(6): 378. [17] Rauer T, Friedl E, Gamble J G, et al. Long-term analysis of chronic pain associated with lower extremity injuries[J]. Arch Orthop Traum Surg, 2023, 143(7): 4149-4154. [18] Hoh M, Geis S, Klein S, et al. Surgical management of secondary complex microsurgical reconstructions after amputation and severe trauma injuries: a case series[J]. Life, 2024, 14(10): 1303. [19] Yang Z, Xu C, Zhu Y G, et al. Radical treatment of severe open fractures of extremities by orthoplastic surgery: a 10-year retrospective study[J]. J Orthop Surg Res, 2021, 16(1): 340. [20] Mathieu L, Mourtialon R, Durand M, et al. Masquelet technique in military practice: specificities and future directions for combat-related bone defect reconstruction[J]. MMR, 2022, 9(1): 48.