微针技术在瘢痕治疗中的临床转化潜力与应用前景

陈媛媛, 祁琳, 路新华, 张磊

武警医学 ›› 2026, Vol. 37 ›› Issue (3) : 253-257.

PDF(984 KB)
PDF(984 KB)
武警医学 ›› 2026, Vol. 37 ›› Issue (3) : 253-257. DOI: 10.3969/j.issn.1004-3594.2026.03.016
综述

微针技术在瘢痕治疗中的临床转化潜力与应用前景

  • 陈媛媛, 祁琳, 路新华, 张磊
作者信息 +
文章历史 +

摘要

经皮载药微针(微针)凭借其微创穿刺皮肤表层以促进药物高效吸收的特性,在皮肤病治疗领域,尤其是瘢痕治疗中展现出显著的应用前景。尽管其具有微创高效的优势,但临床应用效果存在差异以及标准化不足等问题仍待解决。本文综述微针技术在瘢痕治疗中的临床转化能力与具体转化路径,重点围绕该技术的最新研究进展、当前临床转化现状及未来应用前景进行系统分析,以期为相关领域研究者提供参考依据。

关键词

微针 / 材料科学 / 个性化治疗 / 临床转化 / 瘢痕治疗 / 应用前景

引用本文

导出引用
陈媛媛, 祁琳, 路新华, 张磊. 微针技术在瘢痕治疗中的临床转化潜力与应用前景[J]. 武警医学. 2026, 37(3): 253-257 https://doi.org/10.3969/j.issn.1004-3594.2026.03.016
中图分类号: R318   

参考文献

[1] Balieva F, Abebe D S, Dalgard F J, et al. Risk of developing psychiatric disease among adult patients with skin disease:a 9-year national register follow-up study in Norway[J]. Skin Health Dis, 2023, 3(6): e294.
[2] González N, Goldberg D J. Update on the treatment of scars[J]. Drugs Dermatol, 2019, 18(6): 550-555.
[3] Wang J, Huang L, Li J, et al. Efficacy and safety of sequential treatment with botulinum toxin type A, fractional CO2 laser, and topical growth factor for hypertrophic scar management:a retrospective analysis[J]. Scientific Reports, 2024, 14(1): 27233.
[4] Abdin R, Gaumond S I, Yaghi M, et al. Utility of adding platelet-rich plasma to microneedling vs microneedling alone in the treatment of acne scarring[J]. J Drugs Dermatol, 2025, 24(1): 41-46.
[5] Anwar-Fadzil A F B, Yuan Y N, Wang L X, et al. Recent progress in three-dimensionally-printed dosage forms from a pharmacist perspective[J]. J Pharm Pharmacol, 2022, 74(10): 1367-1390.
[6] Morykwas M J, Ditesheim J A, Ledbetter M S, et al. Monodelphis domesticus: a model for early developmental wound healing[J]. Ann Plast Surg, 1991, 27(4): 327-331.
[7] Liu X, Song H, Sun T, et al. Responsive microneedles as a new platform for precision immunotherapy[J]. Pharmaceutics, 2023, 15(5): 1407.
[8] Azizi Machekposhti S, Nguyen A K, Vanderwal L, et al. Micromolding of amphotericin-b-loaded methoxyethylene-maleic anhydride copolymer microneedles[J]. Pharmaceutics, 2022, 14(8): 1551.
[9] Starlin Chellathurai M, Mahmood S, Mohamed Sofian Z, et al. Biodegradable polymeric insulin microneedles - a design and materials perspective review[J]. Drug Deliv, 2024, 31(1): 2296350.
[10] Li S, Wang X, Yan Z, et al. Microneedle patches with antimicrobial and immunomodulating properties for infected wound healing[J]. Adv Sci, 2023, 10: e2300576.
[11] Kim Y C, Park J H, Prausnitz M R. Microneedles for drug and vaccine delivery[J]. Adv Drug Deliv Rev, 2012, 64(14): 1547-1568.
[12] Moffatt K, Quinn C, McCague P J, et al. Exploration into the opinions of patients with HIV, healthcare professionals and the lay public of the use of microneedles in clinical practice: highlighting the translational potential for their role in HIV infection[J]. Drug Deliv Transl Res, 2021, 11(3): 1199-1217.
[13] Mota W M, Salles A G, Remigio A F D N, et al. Microneedling in the treatment of post-burn hypertrophic scars[J]. Aesthetic Plast Surg, 2024, 48(12): 2321-2329.
[14] Lim D Z J, Chun Y Y, Tan F N S Y, et al. Small interfering RNA microneedle patches versus silicone sheets in reducing postoperative scars: a randomized single-blinded intraindividually controlled clinical trial[J]. Br J Dermatol, 2024, 192(1): 19-26.
[15] Jacobs J, Kattapuram M, Rundle C W, et al. The impact on quality-of-life following treatment of surgical facial scars with laser-based therapy: a scoping review[J]. Arch Dermatol Res, 2023, 316(1): 47.
[16] Yang B B, Dong Y T, Shen Y F, et al. Bilayer dissolving mi-croneedle array containing 5-fluorouracil and triamcinolone with biphasic release profile for hypertrophic scar therapy[J]. Bioact Mater, 2021, 6(8): 2400-2411.
[17] Zarei Chamgordani N, Asiaei S, Ghorbani-Bidkorpeh F, et al. A Long-Lasting Triamcinolone-Loaded Microneedle Patch for Prolonged Dermal Delivery[J]. Iran J Pharm Res, 2024, 23(1): e138857.
[18] Xie Y, Wang H, Mao J, et al. Enhanced in vitro efficacy for inhibiting hypertrophic scar by bleomycin-loaded dissolving hyaluronic acid microneedles[J]. Mater Chem B, 2019, 7(42): 6604-6611.
[19] Sitohang I B S, Sirait S A P, Suryanegara J. Microneedling in the treatment of atrophic scars: a systematic review of randomised controlled trials[J]. Int Wound J, 2021, 18(5): 577-585.
[20] Yang Y, Xia L, Ning X, et al. Enhanced drug permeation into human keloid tissues by sonophoresis-assisted microneedling[J]. SLAS Technol, 2021, 26(6): 660-666.
[21] Zhao Y, Wu S, Cai Y, et al. Integration of finite element simulations with 3D printing technology for personalized Chitin/PLA microneedle-based drug delivery systems in thoracic keloid treatment[J]. Int J Biol Macromol, 2025,315: 144487.
[22] Uddin M J, Baig M S, Gholap A D, et al. Advances in 3D printed microneedles as a prototype for skin targeted therapeutics in personalized dermal pharmaceuticals[J]. AAPS PharmSciTech, 2025, 27(1): 49.
[23] Shen S, Shen W, Wang L, et al. Berberine hydrochloride-loaded liposomes-in-hydrogel microneedles achieve the efficient treatment for psoriasis[J]. Mater Today Bio, 2025, 32: 101795.
[24] Yang J, Jin L, Li Y, et al. Advances in drug delivery systems for atopic dermatitis treatment[J]. Chembiochem, 2025, 26(8): e202400968.
[25] Miatmoko A, Hariawan B S, Cahyani D M, et al. Dissolving microneedle patches for delivery of amniotic mesenchymal stem cell metabolite products for skin regeneration in UV-aging induced mice[J]. Eur J Pharm Biopharm, 2024, 204: 114482.
[26] Elakkawi M M J, Zhu Y, Xiong Y, et al. Study on the mechanism of hUCMSCs-derived 3D exosome combined with HAMA microneedles in the treatment of deep second-degree burns[J]. Bioact Mater, 2025, 56: 468-482.
[27] Bigham A, Zarepour A, Khosravi A, et al. Microneedle patches: a new vantage point for diabetic wound treatments[J]. Biomater Sci, 2024, 13(2): 379-407.
[28] Vergilio M M, Birchall J C, Lima L L, et al. Drug delivery systems based in microneedles for dermatological diseases and aesthetic enhancement[J]. Curr Med Chem, 2024, 31(23): 3473-3487.
[29] Derhambakhsh S, Salehi N, Changizi S, et al. From 3D to 6D bioprinting: emerging additive manufacturing technologies for biomedical applications[J]. Biomed Mater, 2025, 12(22).
[30] Yarali E, Mirzaali M J, Ghalayaniesfahani A, et al. 4D Printing for Biomedical applications[J]. Adv Mater, 2024, 36(31):e2402301.
[31] Qin Y, Cui F, Lu Y, et al. Toward precision medicine: end-to-end design and construction of integrated microneedle-based theranostic systems[J]. J Control Release, 2025, 377: 354-375.
[32] Ertas Y N, Ertas D, Erdem A, et al. Diagnostic, therapeutic, and theranostic multifunctional microneedles[J]. Small, 2024, 20: 2308479.

PDF(984 KB)

Accesses

Citation

Detail

段落导航
相关文章

/