目的 分析社区人群血浆致动脉硬化指数(AIP)与小而密低密度脂蛋白胆固醇(sdLDL-C)的相关性,探讨AIP在社区体检中的临床应用价值。方法 选取2018-01至2018-10在广安门医院参加体检的北京市大兴区居民721人,收集一般信息及空腹血糖(FBG)和sdLDL-C等血脂指标。按AIP四分位数分组,比较各组基线特征;采用Spearman相关分析评估AIP与各指标的相关性;采用Logistic回归分析AIP、sdLDL-C与FBG升高(定义为FBG≥6.1 mmol/L)的关系,同时校正性别、年龄、体质量指数(BMI)、吸烟、饮酒等混杂因素。结果 随着AIP四分位数组升高,BMI、FBG、sdLDL-C等血脂指标均显著升高,高密度脂蛋白胆固醇显著下降(P＜0.01)。相关性分析显示,AIP与sdLDL-C呈显著正相关(P＜0.01)。Logistic回归结果显示,在校正混杂因素后,与AIP Q1组相比,Q3组(OR=2.03,95%CI:1.26～3.26,P=0.003)和Q4组(OR=2.64,95%CI:1.63～4.27,P＜0.001) FBG升高的风险显著增加;在校正组中,sdLDL-C在Q4组表现出独立关联性(OR=2.19,95%CI:1.38～3.47,P=0.001)。结论 在社区人群中,AIP与sdLDL-C呈显著正相关,二者均与空腹血糖升高显著相关。AIP作为简便易得的计算指标,在缺乏sdLDL-C检测条件时可部分地替代该指标,并用于识别糖脂代谢异常及动脉粥样硬化高风险人群。
Abstract
Objective To analyze the correlation between atherogenic index of plasma (AIP) and small and dense low-density lipoprotein cholesterol (sdLDL-C) in community population, and to explore the clinical application value of AIP in community physical examinations. Methods A total of 721 residents from Daxing District of Beijing who participated in physical examinations from January to October 2018 were selected. General information, fasting blood glucose (FBG) and blood lipid indexes were collected. The subjects were grouped according to AIP quartile, and the baseline characteristics of each group were compared. Spearman correlation analysis was performed to evaluate the correlation between AIP and each index. Logistic regression analysis was employed to analyze the relationship between AIP, sdLDL-C and the elevated FBG (defined as FBG≥6.1 mmol/L), meanwhile adjustments were made on confounding factors such as gender, age, body mass index (BMI), smoking and alcohol consumption. Results With the increase of AIP quartile, BMI, FBG and sdLDL-C significantly increased, while HDL-C significantly decreased (P＜0.01). Correlation analysis showed that AIP was significantly positively correlated with sdLDL-C (P＜0.01). Logistic regression results showed that compared with AIP Q1 group, the risk of elevated FBG of Q3 group (OR=2.03,95% CI:1.26-3.26,P=0.003) and Q4 group (OR=2.64,95% CI:1.63-4.27, P＜0.001) significantly increased after the adjustment of confounding factors. In the adjusted group, sdLDL-C showed independent correlation with AIP in Q4 group (OR=2.19,95% CI:1.38-3.47,P=0.001). Conclusions There is a significant positive correlation between AIP and sdLDL-C in the community population, and both are significantly related to the elevated FBG. As a simple and readily available calculation index, AIP can partially replace sdLDL-C when detection of the latter is unavailable, and can be used to identify individuals with abnormal glucose and lipid metabolism and high risk of atherosclerosis.
关键词
社区人群 /
血浆致动脉硬化指数 /
小而密低密度脂蛋白胆固醇 /
空腹血糖升高 /
相关性
Key words
community population /
atherosclerosis index of plasma /
small and dense low-density lipoprotein cholesterol /
elevated fasting blood glucose /
correlation
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基金
中国中医科学院科技创新工程项目(CI2022C002);国家中医临床研究示范基地科研专项暨所级科研基金课题(2017S387)
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