目的 探讨蠲痹贴联合常规西药治疗创伤性膝关节炎的临床疗效及对炎症指标影响。方法 选取2024-11至2025-11在东部战区总医院中医科门诊及住院治疗的118例创伤性膝关节炎患者,随机分为对照组(采用NSAIDs)和观察组(NSAIDs基础上采用蠲痹贴穴位贴敷),每组59例。因失访、依从性差等原因共脱落 10 例,最终纳入108例(对照组50例,观察组58例)。分析两组临床疗效及治疗前后VAS疼痛评分、WOMAC评分和Lysholm膝关节评分。结果 观察组的临床控制和显效比例明显高于对照组,疗效分布存在显著的线性趋势,差异有统计学意义(P＜0.05)。两组患者经治疗后VAS疼痛评分、WOMAC评分总分和Lysholm膝关节评分均低于治疗前,差异有统计学意义(P＜0.05)。与对照组比较,观察组的VAS疼痛评分、WOMAC评分、功能评分、Lysholm膝关节评分下降明显,差异有统计学意义(P＜0.05),尤其是急性期VAS疼痛评分,下降更为明显,差异有统计学意义(P＜0.05)。在炎症指标方面,两组治疗后CRP、ESR、IL-6和PCT均明显下降;观察组较对照组下降更为明显,差异有统计学意义(P＜0.05)。结论 蠲痹贴联合常规西药可缓解创伤性膝关节炎患者的关节疼痛,加快膝关节功能恢复。
Abstract
Objective To explore the clinical efficacy of Juanbi plaster combined with conventional western medicine in the treatment of post-traumatic knee osteoarthritis and its effect on inflammatory markers. Methods A total of 118 patients with traumatic knee osteoarthritis treated in the outpatient and inpatient departments of the Traditional Chinese Medicine Department of General Hospital of PLA Eastern Theater Command from November 2024 to November 2025 were selected and randomly divided into a control group (treated with nonsteroidal anti-inflammatory drugs, NSAIDs) and an observation group (treated with Juanbi plaster acupoint application based on NSAIDs), with 59 cases in each group. A total of 10 patients were excluded due to loss to follow-up and poor compliance, and 108 cases were finally included (50 in the control group and 58 in the observation group). The clinical efficacy, Visual Analogue Scale (VAS) pain scores, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, and Lysholm knee scores before and after treatment were analyzed in both groups. Results The proportions of clinical control and marked effectiveness in the observation group were significantly higher than those in the control group, and there was a significant linear trend in efficacy distribution (P<0.05). After treatment, the VAS pain scores, total scores of WOMAC, and Lysholm knee joint scores of both groups were lower than those before treatment, and the differences were statistically significant (P<0.05).Compared with the control group, the observation group showed significantly greater reduction in VAS pain scores, WOMAC scores, functional scores and Lysholm knee joint scores, with statistically significant differences (P<0.05), especially the reduction in VAS pain score during the acute phase,which decreased more significantly,with statistically significant differences (P<0.05).Regarding inflammatory markers, the levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), and procalcitonin (PCT) decreased significantly in both groups after treatment (P<0.05); the reduction in the observation group was more significant than that in the control group, with statistically significant differences (P<0.05). Conclusions Juanbi plaster combined with conventional western medicine can relieve the joint pain and promote the functional recovery of the knee joint in patients with traumatic knee arthritis.
关键词
蠲痹贴 /
非甾体抗炎药 /
穴位贴敷 /
创伤性膝关节炎 /
炎症指标
Key words
Juanbi plaster /
non-steroidal anti-inflammatory drugs /
acupoint application /
post-traumatic knee osteoarthritis;inflammatory markers
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基金
军队系统国家中医药管理局重点专科(专病)建设项目(2007ZDZB001)
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