目的 探讨一种简便、可靠、无损伤、特异性较强的早期诊断阿尔茨海默病（alzheimer disease，AD）的方法。
Abstract
Objective To study the value of urine AD7c-NTP levels for the early diagnosis of Alzheimer disease (AD). Methods Using enzyme linked immunosorbent assay (ELISA), the urine AD7c-NTP level was determined and compared: (1)Thirty-eight patients with dementia & 35 age-matched healthy persons; (2) the levels of urine AD7c-NTP & the scores of MMSE, CDR, ADL. Results The urine AD7c-NTP of AD group and the normal group were（90.78±16.54）ng/ml,（70.63±12.56）ng/ml, respectively. Compared with the normal mental group, the levels of urine AD7c-NTP in AD group were significantly increased (P＜0.05), which was negatively correlated with the scores of MMSE (the examination of mental state), CDR (clinical dementia rating scale) and ADL (activities of daily living scale).The correlations between AD7c-NTP and MMSE (r=0.756), AD7c-NTP and CDR (r=-0.658), and AD7c-NTP and ADL (r=-0.760）were significant in AD patients (all P<0.01).Conclusions Urine AD7c-NTP levels may be an important biochemical marker for the early diagnosis and condition assessment of AD.
关键词
阿尔茨海默病 /
神经丝蛋白 /
智能精神状态检查量表 /
临床痴呆评定量表 /
日常生活能力量表
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参考文献
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