目的 探讨PDE4B、BCL-2在不同类型B细胞非霍奇金淋巴瘤（B cell non-Hodgkin Lymphoma，B-NHL）中的表达及其意义。

Objective To study the expressions of PDE4B and BCL-2 in subgroups of B-cell non-Hodgkin lymphoma (B-NHL) and its significance. Methods Immunohistochemistry technique was used to assess the expressions of PDE4B and BCL-2 in 93 patients with B-NHL, and 10 patients with lymph node reactive proliferation. Results PDE4B and BCL-2 were expressed in different types of lymphoma. Expression of PDE4B was high in LPL,FL and MZL. BL gave negative expression of PDE4B; there was no statistically difference between groups (P>0.05). The expressions of BCL-2 in FL , DLBCL,LBL，and MALT had statistically significant difference(P<0.05).The expression of PDE4B in GCB (germinal center B-cell-like) subgroup of DLBCL（61.54%,16/26）was higher than that in non-GCB subgroup（31.43%,11/35）,with significant difference (P<0.05). Conclusions The expressions of PDE4B and BCL-2 are detected in different types of lymphoma.PDE4B and BCL-2 may play a deteminant role in generating and developing B-NHL. The expression of PDE4B may be negatively correlated with their malignancy and invasiveness.BCL-2 is an important indicator to diagnosis of FL.