目的 评价苹果多酚的安全性。方法 依据食品安全性毒理学评价程序和方法进行急性毒性试验、Ames实验、小鼠骨髓细胞染色体畸变实验、小鼠微核实验和大鼠90 d喂养试验。结果 小鼠经口给予苹果多酚LD₅₀＞10.0 g/kg体重，属实际无毒级; Ames实验、小鼠骨髓细胞染色体畸变实验、小鼠微核实验结果均为阴性； 90 d喂养实验中体重增加和血液学指标值无异常，血液生化指标值在正常值范围内，未见大鼠有系统毒性症状出现。结论 本试验条件下，苹果多酚是安全的。

Objective To evaluate the safety of apple polyphenols. Methods The acute toxicity test, Ames test, bone marrow cell micronucleus test, mouse sperm abnormality test and 90 day feeding test were used in this study according to the procedures for toxicological assessment of foods. Results When the value of LD₅₀ was above 10.0 g/kg BW，apple polyphenols were non-toxic. The results of Ames test, bone marrow cell micronucleus test, and mouse sperm abnormality test were negative. All indexes during the 90 day feeding test were normal. Conclusions Apple polyphenols are safe in this study.