感冒灵胶囊质量标准的研究

许晓莲,王 皎,李 勃

武警医学 ›› 2012, Vol. 23 ›› Issue (10) : 878-880.

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武警医学 ›› 2012, Vol. 23 ›› Issue (10) : 878-880.
论著

感冒灵胶囊质量标准的研究

  • 许晓莲,王 皎,李 勃
作者信息 +

A study on quality standards of Ganmaoling capsules

  • XU Xiaolian,WANG Jiao,and LI Bo. Department of Pharmacy,Shaanxi Provincial Corps Hospital,Chinese People’s Armed Police Forces,Xi'an 710054,China
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摘要

目的 进一步完善感冒灵胶囊的质量标准。方法 采用薄层色谱法鉴别感冒灵胶囊中的三叉苦、岗梅、野菊花;采用HPLC法测定该药中对乙酰氨基酚的含量。结果 在薄层色谱中可见各个鉴别斑点清晰,阴性对照无干扰。 对乙酰氨基酚在0.19894~2.4925 μg范围内线性关系良好,r=0.9999,平均回收率为100.0%,RSD=0.83%。结论 本方法简便易行,重现性好,适于感冒灵胶囊质量控制。

Abstract

Objective To improve the quality standard of Ganmaoling capsules. Methods Evodialepta, holly root, and Chrysanthemum indicum L in Ganmaoling capsules were identified by thin-layer chromatography and the content of paracetamol in this drug was determined by HPLC. Results All the TLC spots developed were clear and the negative controls showed no interference. Paracetamol showed a good linear relationship within a range of 0.1989-2.4925 μg, r=0.9999. The average recovery was 100.0%,and RSD was 0.83%. Conclusions This method is simple, reproducible and can be used for quality control of Ganmaoling capsules.

关键词

感冒灵胶囊 / 薄层色谱法 / 高效液相色谱法

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导出引用
许晓莲,王 皎,李 勃. 感冒灵胶囊质量标准的研究[J]. 武警医学. 2012, 23(10): 878-880
XU Xiaolian,WANG Jiao,and LI Bo. Department of Pharmacy,Shaanxi Provincial Corps Hospital,Chinese People’s Armed Police Forces,Xi'an,China. A study on quality standards of Ganmaoling capsules[J]. Medical Journal of the Chinese People Armed Police Forces. 2012, 23(10): 878-880
中图分类号: R927.11   

参考文献

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[2] 李 嘉,邓治旭.感冒灵胶囊质量标准研究[J].中国试验方剂学杂志,2006,12(5) :11.

[3] 彦 杰,裴建梅.感冒灵流浸膏的质量标准研究[J].广东药学,2005,2(15):33.

[4] 韩正洲, 吴曙光.HPLC测定感冒灵颗粒中对乙酰氨基酚、咖啡因和马来酸氯苯那敏的含量[J].中国药学杂志,2010,45(3):229-230.

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