目的 研究杭州地区部分老年体检人群糖化血红蛋白(glycosylated hemoglobin,HbA1c)水平的分布情况。方法 收集1524例年龄大于60岁的体检人员样本,经全自动糖化血红蛋白分析仪检测HbA1c(%)水平,分析性别及年龄对HbA1c的影响,并比较HbA1c参考值及2010年糖尿病诊断新标准对老年人群糖尿病筛查的价值。结果 老年人中男性与女性HbA1c水平比较差异无统计学意义,60~69岁组中男、女性HbA1c分别为(5.86±0.74)%,(5.77±0.67)%,70~79组中男、女性HbA1c分别为(5.90±0.91)%,(5.96±0.78)%,男性和女性60~ 69岁组与70 ~ 79岁组间差异均具有统计学意义(P<0.05)。结论 杭州地区老年人群男性与女性HbA1c总体水平相似,各年龄组HbA1c水平略有差异。依照2010年糖尿病诊断新标准筛查出糖尿病者疑似病例增多,为临床中糖尿病的早期发现提供了诊断指标。
Abstract
Objective To investigate the distribution of glycosylated hemoglobin (HbA1c) levels in senior populations in Hangzhou. Methods 1524 elderly people undergoing physical examinations in this hospital between January 2012 and June 2012 were recruited into this study. HbA1c (%) levels were detected by an automatic glycated haemoglobin analyzer, and the results were statistically analyzed by gender and age. We also evaluated the 2010 new criteria for diagnosis of diabetes mellitus. Results The distribution of HbA1c(%) levels was not significantly different in different gender groups, and the levels of HbA1c(%) increased in 70-79 age groups. Conclusions The HbA1c levels in elderly people are similar among males and females but vary to some extent between different age groups. According to 2010 Guidelines, the number of patients with suspected diabetes mellitus has increased, making necessary early detection and early treatment of diabetes to reduce the incidence of diabetic complications.
关键词
老年人 /
糖化血红蛋白 /
糖尿病
Key words
elderly people /
glycosylated hemoglobin /
diabetes mellitus
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参考文献
[1] World Health Organization. Definition, diagnosis and classifications of diabetes mellitus and its complications. Report of a WHO consultation, part 1: diagnosis and classification of diabetes mellitus[R]. Geneva: WHO, 1999.
[2] American Diabetes Association. Diagnosis and classification of diabetes mellitus[J].Diabetes Care, 2010, 33(1): S62–S69.
[3] American Diabetes Association. Standards of medical care in diabetes[J]. Diabetes Care, 2007,30( Suppl 1): S4-S41.
[4] 王 群, 常文青, 安秀英, 等. 邢台市4098 例糖化血红蛋白检测调查分析[J]. 中国误诊学杂志, 2009, 9 (33): 8311-8312.
[5] 刘志军, 谭东云, 饶 荣. 糖化血红蛋白联合糖化血清蛋白检测在鉴别高血糖性质中的应用[J]. 中华实用诊断与治疗杂志, 2011, 25(1): 67-68.
[6] American Diabetes Association. Standards of medical care in diabetes-2011[J]. Diabetes Care, 2011, 34(Suppl. 1): S11-S61.