目的 探讨维持性血液透析(maintenance hemodialysis，MHD)患者微炎症状态与颈动脉内中膜厚度进展(progression of carotid intima-media thickness，PROG-IMT)的相关性。方法 ELISA 法测定对武警后勤学院血液净化中心93 例符合标准的MHD患者高敏C反应蛋白水平（hs-CRP），据结果分为正常组（30例，hs-CRP水平 0.05）；因心脑血管疾病死亡1例。(2)PROG-IMT 与hs-CRP、年龄、血压、低密度脂蛋白正相关（P<0.05）。(3)多元逐步回归分析显示，hs-CRP 是影响PROG-IMT 的主要因素（P<0.05）。结论 微炎症状态MHD 患者IMT 呈进行性进展，血清hs-CRP 水平是影响PROG-IMT 的主要因素。
Abstract
Objective To explore the correlation between the micro-inflammatory state of patients of maintenance hemodialysis and progression of carotid intima-media thickness (PROG-IMT). Methods The high-sensitivity C-reactive protein level (hs-CRP) of 93 standard-compliant MHD patients was measured by ELISA. According to the results, these patients were divided into normal group (30 cases, hs-CRP levels 0.05). There was one death from cardiovascular and cerebrovascular diseases. (2) PROG-IMT, hs-CRP, age, blood pressure, and low density lipoprotein were positively correlated (P<0.05). (3) Stepwise multiple regression analysis showed that hs-CRP was a major factor affecting PROG-IMT (P<0.05). Conclusion IMT of MHD patients with micro-inflammatory status is progressive and hs-CRP levels are the main factor that affects PROG-IMT.
关键词
微炎症 /
颈动脉内中膜厚度 /
进展 /
血液透析 /
相关性
Key words
micro-inflammatory;carotid intima-media thickness;progression /
hemodialysis /
correlation
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(2012-07-18
基金
天津市自然科学基金（09JCYBJC09900）
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