目的 探讨急性脑梗死合并代谢综合征（metabolic syndrome，MS）对脂蛋白相关磷脂酶A2(lipoprotein- associated phospholipase A-2, Lp-PLA-2)的影响。 方法 根据国际糖尿病联盟（IDF）MS诊断标准，将74例急性脑梗死患者分为MS组及非MS组两组。检测各组血浆高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、三酰甘油（TG）及总胆固醇（TC）水平与腰围。 结果 MS组LP-PLA2水平（38.87±5.44）较非MS组（36.44±4.15）明显升高，两组比较差异有统计学意义（ P =0.037）。同时伴有TG明显升高及腰围的差异。 结论 MS患者Lp-PLA2水平升高，Lp-PLA2可能与MS相关。
Abstract
Objective To investigate the level of blood plasma Lp-PLA-2 in patients with acute cerebral infarction complicated by metabolic syndrome（MS) and to investigate the correlation between LP-PLA and MS. Methods We studied 74 hospitalized patients with acute cerebral infarction. They were divided into MS group and non-MS group according to the criteria of MS published by International Diabetes Federation (IDF). The level of blood plasma Lp-PLA-2 and blood serum TC, TG, LDL-C, HDL-C was detected by ELISA. Results Significant difference was observed between patients with acute cerebral infarction complicated by MS in levels of plasma Lp-PLA-2 and non-MS group (38.87±5.44 vs 36.44±4.15, P =0.037). The level of serum triglyceride(TG) was also higher ( P <0.05). Conclusions MS induces elevation of the level of plasma Lp-PLA-2.
关键词
脂蛋白相关磷脂酶A-2 /
代谢综合征 /
急性脑梗死
Key words
lipoprotein- associated phospholipase A-2 /
metabolic syndrome /
acute cerebral infarction
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