目的 研究新诊断2型糖尿病患者分别接受持续性皮下胰岛素输注(continuous subcutaneous insulin infusion，CSⅡ)和多次皮下注射胰岛素(multiple subcutaneous insulin injection，MSⅡ)治疗对胰岛素抵抗的影响。 方法 新诊断的2型糖尿病患者分别接受CSⅡ和MSⅡ治疗2周，计算胰岛素敏感指数（SIM），评价胰岛素敏感性的变化。 结果 治疗后CSⅡ组SIM（26.98±11.99）较MSII组SIM（22.14±9.00）明显升高，两组比较差异有统计学意义（ P =0.042）。 结论 新诊断的2型糖尿病患者短期应用胰岛素泵强化治疗可增加胰岛素的敏感性。
Abstract
Objective To evaluate the variance of insulin resistance after continuous subcutaneous insulin infusion (CSⅡ) or multiple subcutaneous injection (MSⅡ) therapy in newly diagnosed type 2 diabetic patients. Methods Sixty newly diagnosed type 2 diabetic patients were randomly divided into two groups: CSⅡ and MSⅡ group. SIM were calculated to evaluate the variance of insulin sensitivity. Results SIM（26.98±11.99）were significantly higher in CSⅡ group than （22.14±9.00）in MSⅡ group, P =0.042. Conclusions Short-term CSⅡ can effectively increase insulin sensitivity in newly diagnosed type 2 diabetic
关键词
2型糖尿病 /
胰岛素泵 /
胰岛素抵抗
Key words
type 2 diabetes /
insulin pump /
insulin resistance
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