目的 研究笑气（N 2O）清醒镇静在肠镜检查中的安全性和有效性。 方法 将 2011-04至2011-12在我院行笑气清醒 镇静肠镜检查的330例患者作为A组，同期常规肠镜检查300例患者作为B组，对其HR、SpO 2、反应情况及镇静效果等进行研 究分析。 结果 A组术中不适反应明显低于B组。A组中，术中HR低于术前［（74.90±13.65）次/min vs （79.16±14.67）次/min， P ＜0.05］，但术中HR在正常安全范围内；术中SpO 2高于与术前［99.64±1.04）% vs （99.14±1.35）%， P ＜0.05］。B组中，术中HR高于术前［（89.80±13.52） vs (79.77±13.35)， P ＜0.05］ ；术中SpO 2稍低于与术前［（99.42± 1.07 ）% vs (99.53±1.12)%］，但差异无统计学意义。 结论 笑气清醒镇静肠镜检查提高了肠镜检查的舒适度，安全、可行。
Abstract
Objective To study the safety and effectiveness of nitrous oxide (≤70%) for colonoscopy. Methods A total of 630 patients who underwent colonoscopy from April 2011 to December 2011 were divided into group A (nitrous oxide-colonoscopy group, n =330) and group B (conventional colonoscopy group, n =300). Their heart rate (HR), oxygen saturation and sedative effects were compared. Results The perioperative reaction in group A was obviously lower than in group B. In group A, the perioperative HR was obviously lower than the preoperative HR ［（74.90±13.65） vs (79.16±14.67)， P ＜0.05］ and the perioperative SpO2 was significantly higher than the preoperative SpO2 ［（99.64±1.04）% vs (99.14± 1.35)%， P ＜0.05］. In group B, the perioperative HR was significantly higher than the preoperative HR （89.80±13.52） vs (79.77±13.35)， P ＜0.05］ and the perioperative SpO2 was slightly higher than the preoperative SpO2 ［（99.64±1.04）% vs （99.14±1.35）%， P ＜0.05］，but the difference was not statistically significant. Conclusions Nitrous oxide for colonoscopy is comfortable, safe and feasible.
关键词
笑氧混合气（笑气浓度&le /
70%） /
清醒镇静 /
下消化道 /
肠镜 /
评价
Key words
nitrous oxide /
conscious sedation /
lower gastrointestinal tract /
colonoscopy /
evaluation
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参考文献
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