目的 探讨胃间质瘤（gastric stromal tumors, GST）的临床特点及治疗。方法 回顾性分析2010-01至2012-01我院收治的经手术病理证实的34例GST临床资料。结果 主要临床表现为腹部不适或疼痛（11例），腹部肿块（14例），上消化道出血、黑便（5例），体检及其他手术中发现（4例）。肿瘤发生于胃窦15例，胃体11例，胃底8例。本组所有患者均行手术治疗且行病理检查。免疫组化结果显示：CD117的阳性率为94.1 %（32/34），CD34的阳性率为73.5 %（25/34）。32例获得随访，术后复发7例，4例予以伊马替尼治疗，疗效显著。结论 GST的确诊需术后病理及免疫组化，外科手术仍是GST治疗的首选方式，术后适当的靶向治疗可改善其预后。
Abstract
Objective To investigate the clinical characteristics and treatment of gastric stromal tumors(GST). Methods The clinical data of patients with proved pathologically gastric stromal tumors admitted from January 2010 to January 2012 were analyzed retrospectively. Results The tumors originated from gastric antrum（n=15）, gastric corpus(n=11),and gastic fundus(n=8), separately.The clinical manifestations found in patients with GST included abdominal discomfort or pain(n=11), abdominal mass(n=14), gastrointestinal bleeding or melena(n=5),and 4 cases were found in physical examination or other surgery (n=4).All the GSTs in this group underwent operation and pathological examination . Immunohistochemical determination revealed that the positive rates of CD117 and CD34 were 94.1% and 73.5% respectively. 32 cases were followed up and 4 cases of recurrent GST received imatinib mesylate therapy. Conclusions The diagnosis of GST should be confirmed by postoperative pathological and immunohistochemical examination Surgery is the main therapy and appropriate targeted therapy improves the survival.
关键词
胃间质瘤 /
诊断 /
外科手术
Key words
gastric stromal tumor /
diagnosis /
surgery
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参考文献
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