目的 观察前列地尔注射液联合高压氧治疗对急性重度一氧化碳中毒的疗效。方法 将110例急性重度一氧化碳中毒患者随机分为前列地尔组与对照组，对照组给予高压氧及内科综合治疗；前列地尔组在对照组基础上联用前列地尔注射液10 μg， 1次/d,静滴，疗程为14 d。比较两组24 h清醒率、迟发性脑病发生率等。结果 前列地尔组总有效率92.8%，明显优于对照组79.6%（P＜0.05）。前列地尔组在降低病死率、减少迟发性脑病及脑梗死发生率方面，与对照组相比具有减少趋势，但差异无统计学意义。结论 前列地尔注射液联合高压氧治疗急性重度一氧化碳中毒有明显优势，能有效促进重症患者功能恢复，降低病死率，减少迟发性脑病及脑梗死发生率。

Objective To investigate the effect of Alprostadil Injection combined with hyperbric oxygen in treatment of acute severe carbon monoxide.Methods 110 patients with acute severe carbon monoxide were randomly divided into control group and treatment group. All the cases received the hyperbaric oxygen therapy based on the internal comprehensive treatment. Then, treatment group was treated with Alprostadil Injection 10 μg/d，which lasted 14 days.Results The total effective rate was 92.8% in treatment group, much higher than in the control group (P＜0. 05). The rate of fatality and delayed encephalopathy after acute carbon monoxide poisoning and cerebral infarction was significantly reduced in the control group,but there was no statistical significance.Conclusion Alprostadil Injection combined with hyperbric oxygen for treating acute severe carbon monoxide can facilitate the recovery of functions while reducing delayed encephalopathy after acute carbon monoxide poisoning and cerebral infarction.