目的 研究胶质细胞瘤转录因子1（glioma-associated oncogene homolog 1, Gli1）在乳腺浸润性导管癌中的表达情况和临床意义。方法 通过免疫组化Envision法检测Gli1在乳腺浸润性导管癌及癌旁组织的表达情况，分析乳腺浸润性导管癌中Gli1表达与年龄、肿瘤大小、临床TNM分期、淋巴转移、雌激素受体（ER）、孕激素受体（PR）、P53、人类表皮生长因子受体-2（HER-2）表达的关系。 结果 乳腺浸润性导管癌中Gli1的表达明显高于癌旁组织（χ2=10.996,P <0.01)。Gli1的表达与肿瘤大小、TNM分期、P53表达正相关，差异有统计学意义（分别χ2=4.621, χ2=4.332, χ2=4.601，P<0.05）；与年龄、淋巴结转移、ER、PR、HER-2表达无明显相关，差异无统计学意义。 结论 Gli1的表达是辅助诊断乳腺癌的新指标，Gli1表达促进乳腺浸润性导管癌肿瘤生长、分期进展，Gli1表达可能与P53的调控有关。
Abstract
Objective To investigate the expression of Glioma-associated Oncogene Homolog 1 (Gli1) in breast infiltrating ductal carcinoma and the clinical significance. Methods Gli1 expression in breast infiltrating ductal carcinoma and pericarcinomatous tissues was examined by Envison immunohistochemistry. The relationship between Gli1 expression, age, tumor size, clinical TNM stages, lymph node metastasis, Estrogen Receptor (ER), Progesterone Receptor (PR), P53, human epidermal growth factor receptor-2 (HER-2) expression in breast infiltrating ductal carcinoma was analyzed. Results GLi1 expression in breast infiltrating ductal carcinoma tissues was higher than in pericarcinomatous tissues (χ2=10.996,P <0.01). Gli1 expression was positively correlated with tumor size, P53 and clinical TNM stages, but not correlated with age, lymph node metastasis, ER, PR or HER-2. There was significant difference (χ2=4.621, χ2=4.332, χ2=4.601,P<0.05). Conclusion Gli1 expression is a new diagnostic parameter for breast carcinoma. It promotes tumor growth and development of clinical stages in breast infiltrating ductal carcinoma. Gli1 expression may be regulated by P53 expression.
关键词
乳腺癌 /
胶质细胞瘤转录因子1 /
免疫组织化学
Key words
breast cancer /
Gli1 /
immunohistochemistry
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