目的 研究血清C反应蛋白（CRP）与白细胞在不同类型小儿肺炎的变化情况及CRP、 白细胞联合检测对小儿肺炎的诊断价值。方法 以我院758例肺炎患儿为研究对象，根据肺炎确诊类型分为细菌组212例、病毒组287例及支原体组259例，并以142例健康体检儿童为对照组，研究各组别CRP、白细胞计数及分类的检测情况及肺炎患儿CRP在病程的变化情况。结果 4组 CRP血清水平、白细胞计数、LYMPH、NEUT各指标经方差分析差异均有统计学意义（P＜0.05）；CRP异常率、白细胞异常率经卡方检验分析差异也存在统计学意义（P＜0.05）；3组肺炎患儿CRP血清水平细菌组恢复期下降比较快，病毒组无明显变化。结论 CRP、白细胞联合检测在肺炎早期诊断、临床抗生素的合理使用、防止耐药菌群的产生方面有积极的作用。

Objective To study the serum CRP concentration and WBC count changes in different types of pediatric pneumonia and the diagnostic value of CRP and WBC combined detection in children with pneumonia. Metheds 758 cases of pneumonia at our hospital were studied. They were divided into bacterial group(212 cases), virus group (287 cases) and mycoplasma group (259 patients) according to the type of pneumonia, with 142 healthy children as control. CRP, WBC and WBC classification detection were studied and CRP changes were observed in the course of the disease. Results The analysis of variance showed that each index of CRP, WBC, LYMPH, NEUT in the four groups was statistically different (P＜0.05). The abnormal rate of CRP and WBC was also statisticaly different (P＜0.05) by chi-square analysis. CRP in the bacterial group decreased faster during recovery while virus group showed no significant change. Conclusion CRP and WBC combined application plays a positive role in early diagnosis of pneumonia, clinical rational use of antibiotics and prevention of resistant bacteria.