目的 观察米非司酮分别与米索前列醇、依沙吖啶联合用于终止14~27周妊娠的临床效果及安全性。方法 选择妊娠14~27周，自愿要求终止妊娠的健康女性120例，随机分为A、B两组，A组60例予米非司酮、米索前列醇序贯口服；B组60例予米非司酮口服、依沙吖啶羊膜腔注射。观察两种引产方法的成功率、手术清宫率、用药至分娩时间、出血量、药物不良反应及并发症。结果 米非司酮分别与米索前列醇、依沙吖啶联合用于终止14~27周妊娠均取得较好效果，在流产成功率、出血量、安全性方面差异无统计学意义。前者无需羊膜腔给药，手术清宫率低于后者（P＜0.05），减少了医源性感染的机会，但较大孕周时米索前列醇的给药间隔及用量需在严密监测下根据个体差异适时调整，因此更适合应用于终止16周以下妊娠；后者用药方法相对简单、安全，值得在16周以上中期引产推广使用。结论 米非司酮分别与米索前列醇、依沙吖啶联合用于中期妊娠流产的方法，效果确切，不良反应及并发症少，值得临床推广。
Abstract
Objective To observe the efficacy and safety of using mifepristone combined with misoprostol and ethacridine respectively in induced termination of pregnancy during the second and third trimester. Methods 120 women undergoing legal induced abortion during the second and third trimester were divided randomly into two groups. Group A with 60 patients were given oral mifepristone and misoprostol sequentially while 60 patients in group B were given mifepristone orally and ethacridine by amniotic injection. The rate of success and surgical evacuation, induction-abortion interval, blood loss, side effects and complications were observed. Results Both methods achieved good results, without significant difference in terms of bleeding or safety. The former, without amniotic administration, had a lower surgical evacuation rate than the latter (P
关键词
妊娠中期 /
引产 /
米非司酮 /
米索前列醇 /
依沙吖啶
Key words
second trimester pregnancy /
induced abortion /
mifepristone /
misoprostol /
ethacridine
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参考文献
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