目的 研究高尿酸水平对葡萄糖氧化酶法与己糖激酶法测定血糖的影响。方法 用葡萄糖氧化酶法和己糖激酶法在迈瑞BS300生化分析仪上分别测定42例高尿酸血症患者和50例健康人血糖水平，比较两法结果的差异及相关性。结果 高尿酸血症组葡萄糖氧化酶法和己糖激酶法血糖结果分别为（6.61±1.64）mmol/L和（7.17±1.66）mmol/L，两方法的血糖结果存在差异，葡萄糖氧化酶法受血尿酸影响，结果低于真值，血尿酸浓度与两法结果的差值正相关。结论 应用葡萄糖氧化酶法检测高尿酸血症患者血糖水平会导致结果偏低，需要修正或换用己糖激酶法。
Abstract
Objective To study the effect of hyperuricemia on the determination of fasting glucose using glucose oxidase method and hexokinase method. Methods Blood glucose levels in forty-two hyperuricemic patients and 50 healthy subjects were measured by oxidase method and hexokinase method using Mindray BS300 biochemistry analyzer. The difference and relevance between the two Methods were investigated. Results The blood glucose result by glucose oxidase method was（6.61±1.64） mmol/L while that by hexokinase method was （7.17±1.66）mmol/L.The result of oxidase method was below the true value. There was positive correlation between the uric acid value and the difference of blood glucose Results in hyperuricemic group. Conclusions The blood glucose value tends to be low by glucose oxidase method. Either correction or hexokinase method is needed.
关键词
高尿酸血症 /
葡萄糖氧化酶法 /
己糖激酶法 /
血糖测定
Key words
hyperuricemia /
glucose oxidase method /
hexokinase method /
serum glucose determination
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