目的 通过与原发性高血压患者比较血管内皮功能，探讨睡眠呼吸暂停(obstructive sleep apnea，OSA)相关性高血压发病机制，以期指导临床治疗。方法 睡眠呼吸暂停相关性高血压患者37例作为OSA组，原发性高血压患者38例作为原发性组，比较两组一般资料和血管性血友病因子(von Willebrand Factor， vWF)、肱动脉内皮依赖性舒张功能(endothelium-dependent dilation，EDD)和非内皮依赖的舒张功能(endothelium independent dilation， EID)。结果 BMI、收缩压、舒张压比较无统计学意义，但空腹血糖比较有统计学意义(P<0.05);OSA组vWF(167.13±15.41)%较原发性组(129.04±13.32)%升高，EDD(4.12±0.43)%较原发性组(6.89±0.54)%降低，差异均有统计学意义(P<0.05)，OSA组EID与原发性组比较无统计学意义。结论 睡眠呼吸暂停相关性高血压的发生、发展与内皮功能障碍密切相关;内皮功能检测可指导其临床治疗。

Objective To study the pathogenesis and guide clinical treatments of sleep apnea-related hypertension by comparing the endothelial function with patients suffering from primary hypertension. Methods The differences in general data, vWF, EDD and EID between 37 patients with sleep apnea-related hypertension (OSA group) and 38 patients with primary hypertension (primary group) were observed. Results There were no significant differences in BMI, systolic blood pressure and diastolic blood pressure. There were significant differences in fasting blood glucose(P<0.05).The result of vWF in OSA group was (167.13?15.41)%, while that in primary group was (129.04?13.32)%. The result of EDD in OSA group was (4.12?0.43)%, while that in primary group was(6.89?0.54)%. Increase of vWF and decrease of EDD in OSA group were significantly different(P<0.05).There were no significant differences in EID between OSA group and primary group. Conclusions The generation and development of sleep apnea-related hypertension are closely related with endothelial dysfunction . Detection of endothelial function may guide clinical treatments of sleep apnea-related hypertension.